{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:46:40Z","timestamp":1777441600159,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous malignancy with a propensity to metastasize to regional lymph nodes. Sentinel lymph node biopsy (SLNB) in patients with clinically node\u2010negative MCC has been utilized to identify patients with subclinical nodal metastases. This study aims to review the accuracy of SLNB in MCC and to evaluate the impact of SLNB on management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with clinically node\u2010negative MCC who underwent SLNB were identified from a prospective database of patients treated at the Westmead Hospital, Sydney, between 1998 and 2017. Data from these patients were reviewed and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010one patients were identified: 28 men and 13 women, median age 70\u2009years. Median duration of follow\u2010up was 27\u2009months. Sixteen (39%) patients had a positive SLNB and all underwent nodal treatment which consisted of radiotherapy (<jats:italic>n<\/jats:italic>\u2009=\u200913), completion lymphadenectomy and adjuvant radiotherapy (<jats:italic>n<\/jats:italic>\u2009=\u20092), and completion lymphadenectomy alone (<jats:italic>n<\/jats:italic>\u2009=\u20091). Following negative SLNB, 24 of 25 patients did not undergo further nodal treatment. The false\u2010negative rate was 16% as three patients developed in\u2010field nodal recurrence subsequent to a negative SLNB. At last follow\u2010up, 29 patients had no evidence of disease, six were alive with disease and three had died from other causes. Three SLN\u2010positive patients have died of MCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLNB has a high rate of positivity and can improve the accuracy of staging and prognostication in MCC, and guide management. The relatively low risk of a false\u2010negative SLNB justifies close observation in SLNB\u2010negative patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.15228","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T23:49:53Z","timestamp":1554767393000},"page":"520-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Sentinel lymph node biopsy in clinically node\u2010negative Merkel cell carcinoma: the Westmead Hospital experience"],"prefix":"10.1111","volume":"89","author":[{"given":"Lillian N.","family":"Jenkins","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3634-246X","authenticated-orcid":false,"given":"Julie 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