{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:20:30Z","timestamp":1781698830835,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T00:00:00Z","timestamp":1560988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The main aims of this study are to investigate the clinical application value of using indocyanine green fluorescence imaging for ensuring complete resection of tumour tissue during hepatectomy and to evaluate the diagnostic efficacy of near\u2010infrared (NIR) fluorescence imaging system using indocyanine green in hepatectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After undergoing liver resection at the Affiliated Hospital of Southwest Medical University from July 2017 to May 2018, 35 eligible patients were included in this study. The liver surface and resection margin were intraoperatively assessed by intraoperative ultrasonography and NIR fluorescence imaging, after intravenous administration of indocyanine green (0.5 mg\/kg) 72\u201396\u2009h prior to surgery. The intraoperative observations were compared with the pathological findings in the liver.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 35 patients, a total of 53 lesions were found, of which 42 were malignant lesions. The analysis results showed that the sensitivity and accuracy of detection using NIR fluorescence imaging were significantly higher than with intraoperative ultrasonography (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). However, there was no difference between contrast\u2010enhanced helical computed tomography and NIR fluorescence imaging in finding lesions (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). In addition, 11 new suspicious lesions were detected only by NIR fluorescence imaging in the liver surface and resection margin during surgery, four of which were hepatocellular carcinoma. We also detected four vein tumour thrombi using the NIR fluorescence navigation system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The NIR fluorescence navigation system enables the identification of small tumours, residual cancer tissues in resection margin and venous tumour embolies in real time and enhances the accuracy and integrity of liver resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.15282","type":"journal-article","created":{"date-parts":[[2019,6,20]],"date-time":"2019-06-20T07:57:10Z","timestamp":1561017430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Residual cancerous lesion and vein tumour thrombus identified intraoperatively using a fluorescence navigation system in liver surgery"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2171-6174","authenticated-orcid":false,"given":"Pan","family":"He","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Hospital of Southwest Medical University  Luzhou China"},{"name":"Department of Anesthesiology Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Affiliated Hospital of Southwest Medical University  Luzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwei","family":"Chi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Imaging Institute of Automation, Chinese Academy of Sciences  Beijing China"},{"name":"Beijing Digital Precision Medicine Technology Co. 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