{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:40:22Z","timestamp":1792615222075,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T00:00:00Z","timestamp":1567468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We conducted a systematic review and meta\u2010analysis to identify potentially modifiable risk factors for multidrug\u2010resistant Gram\u2010negative colonization or infection in critically ill burn patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted of PubMed, Embase, CINAHL, Web of Science and Central (Cochrane). Risk factors including antibiotic use and hospital interventions were summarized in a random\u2010effects meta\u2010analysis. Risk of publication bias was assessed using the Grading of Recommendations Assessment, Development and Evaluation method and funnel plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 studies met the inclusion criteria. We identified several potentially modifiable risk factors and were able to grade their importance based on effect size. Related to prior antibiotic exposure, extended\u2010spectrum cephalosporins (pooled odds ratio (OR) 7.00, 95% confidence interval (CI) 2.77\u201317.67), carbapenems (pooled OR 6.65, 95% CI 3.49\u201312.69), anti\u2010pseudomonal penicillins (pooled OR 4.23, 95% CI 1.23\u201314.61) and aminoglycosides (pooled OR 4.20, 95% CI 2.10\u20138.39) were most significant. Related to hospital intervention, urinary catheters (pooled OR 11.76, 95% CI 5.03\u201327.51), arterial catheters (pooled OR 8.99, 95% CI 3.84\u201321.04), mechanical ventilation (pooled OR 5.49, 95% CI 2.59\u201311.63), central venous catheters (pooled OR 4.26, 95% CI 1.03\u201317.59), transfusion or blood product administration (pooled OR 4.19, 95% CI 1.48\u201311.89) and hydrotherapy (pooled OR 3.29, 95% CI 1.64\u20136.63) were most significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prior exposure to extended\u2010spectrum cephalosporins and carbapenems, as well as the use of urinary catheters and arterial catheters pose the greatest threat for infection or colonization with multidrug\u2010resistant Gram\u2010negative organisms in the critically ill burn patient population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.15393","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T23:15:47Z","timestamp":1567552547000},"page":"1256-1260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Modifiable risk factors for multidrug\u2010resistant Gram\u2010negative infection in critically ill burn patients: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2831-404X","authenticated-orcid":false,"given":"Mark L.","family":"Vickers","sequence":"first","affiliation":[{"name":"Faculty of Medicine The University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Malacova","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Brisbane Queensland 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