{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:11Z","timestamp":1787013851610,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>No consensus regarding the best post\u2010operative treatment option for air leak has been established. In this study, we evaluate the use of intra\u2010pleural fresh frozen plasma (FFP) as a promising treatment method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Treatment for a sustained air leak (3\u2009days) was warranted in approximately 12% of the lung surgeries at our institution. Fifty\u2010two patients were treated with FFP by application of 250\u2009mL daily. The patients were divided into two cohorts: cohort 1 consisted of 35 patients undergoing anatomical lung resections and cohort 2 consisted of 17 patients after miscellaneous types of lung surgery. Successfulness of the procedure as well as the potential influential factors was evaluated statistically and validated by a bootstrapping. Area under receiver operating characteristic curve was used to establish a cut\u2010off value of the predictor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the first cohort, air leakage was successfully treated in 28 (80%), while in seven (20%) it was still present after third treatment with FFP. The success rate in cohort 2 was 76.5%. The only covariate which appeared to remain significant in both cohorts was flow as displayed on the digital suction device prior to application of FFP. Flow \u2264375\u2009mL\/min was indicative of successful aerostasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intra\u2010pleural instillation of FFP seems to be a feasible method for the treatment of post\u2010operative air leakage. Although the optimum strategy regarding its application as well as its limitations is yet to be established, an absence of complications or undesirable events makes this (off label) method a safe and promising alternative to existing options.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.15451","type":"journal-article","created":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T23:59:16Z","timestamp":1569887956000},"page":"144-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New method in treatment of post\u2010operative air leakage with fresh frozen plasma"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-3471","authenticated-orcid":false,"given":"Davor","family":"Stamenovic","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery ViDia Kliniken Karlsruhe  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Messerschmidt","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery ViDia Kliniken Karlsruhe  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Steger","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department Clinic of Thoracic, Cardiac and Vascular Surgery, T\u00fcbingen University Hospital  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery ViDia Kliniken Karlsruhe  Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.08.069"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.06.066"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2004.11.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.04.033"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.6.1507"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.02.050"},{"key":"e_1_2_8_8_1","first-page":"749","article-title":"Plasma proteins and wound healing","volume":"153","author":"Powanda MC","year":"1981","journal-title":"Surg. 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