{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:27:18Z","timestamp":1775705238631,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Optimal management of regional lymph nodes for thin cutaneous melanoma is uncertain. We evaluated regional lymph node involvement and 5\u2010year melanoma\u2010specific survival (MSS) in patients with thin (\u22641\u2009mm) primary melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with a melanoma, American Joint Committee on Cancer Staging 8th Edition pT1a (&lt;0.8\u2009mm) or pT1b (ulceration; and\/or 0.8\u20131.0\u2009mm), diagnosed during 2001\u20132015 were identified from the Queensland Oncology Repository. We extracted demographic, pathology and clinical details, including sentinel lymph node biopsy (SLNB), regional nodal dissection and nodal recurrence. Poisson regression was used to assess recurrence risk in patients who did not undergo SLNB. The 5\u2010year MSS was calculated using the Kaplan\u2013Maier method with Cox regression to compare survival outcomes according to SLNB performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 27\u2009824 eligible patients, 240 (0.9%) underwent SLNB. One hundred and seventy\u2010eight patients (0.6%) without SLNB had nodal recurrence. Of the 4848 patients with a pT1b lesion, 166 (3.4%) had SLNB with 12 (7.2%) positive; of the remainder, 99 (2.1%) had clinical recurrence. Risk of recurrence was higher in males, nodular subtype and T1b lesions and lower if patients were aged &gt;60\u2009years. The 5\u2010year MSS was similar for observed and SLNB cohorts (99.66% versus 98.92%) but worse for T1b lesions (98.90%) and clinical nodal recurrence (66.89%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall prognosis for T1 melanoma is excellent with nodal involvement being rare. However, the American Joint Committee on Cancer 8th Edition T1b melanoma correlates with significantly worse 5\u2010year MSS and increased regional nodal recurrence (notably for 0.8\u20131.0\u2009mm lesions with ulceration). Further characterization of high\u2010risk groups for nodal positivity that impacts patient outcome is needed for the pT1 melanoma cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.15804","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T11:58:32Z","timestamp":1584014312000},"page":"503-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Regional nodal metastasis and 5\u2010year survival in patients with thin melanoma in Queensland: a population\u2010based study"],"prefix":"10.1111","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-4573","authenticated-orcid":false,"given":"Harrison","family":"Theile","sequence":"first","affiliation":[{"name":"Discipline of Surgery The University of Queensland  Brisbane Queensland Australia"},{"name":"Queensland Cancer Control Analysis Team Cancer Alliance Queensland  Brisbane Queensland Australia"},{"name":"Queensland Melanoma Project Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Moore","sequence":"additional","affiliation":[{"name":"Queensland Cancer Control Analysis Team Cancer Alliance Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Dunn","sequence":"additional","affiliation":[{"name":"Queensland Cancer Control Analysis Team Cancer Alliance Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danica","family":"Cossio","sequence":"additional","affiliation":[{"name":"Queensland Cancer Control Analysis Team Cancer Alliance Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Forristal","sequence":"additional","affiliation":[{"name":"Queensland Melanoma Collaborative  Brisbane Queensland Australia"},{"name":"Mater Research Institute  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2753-4841","authenticated-orcid":false,"given":"Adele C.","family":"Green","sequence":"additional","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"CRUK Manchester Institute University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8333-8685","authenticated-orcid":false,"given":"B. 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