{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:38:49Z","timestamp":1747183129847,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stage 2 colonic cancer comprises a heterogeneous group of patients with a spectrum of disease, from invasion of the sub\u2010serosa to tumour perforation into visceral peritoneum\/adjacent organs. This study evaluates the post\u2010operative outcomes and prognostic factors of patients with both emergency and elective presentations of stage 2 colonic cancer treated with curative intent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of a prospectively maintained database of adult patients (emergency and elective) who underwent curative surgery for stage 2 colonic cancer in a single tertiary referral centre between 2007 and 2016 was conducted. Multivariate analysis was performed to identify prognostic factors. Measured variables included demographics, complications, histology, disease\u2010free survival and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 428 patients with stage 2 colonic cancer received curative surgical resection, and negative resection margins were achieved in all cases: T3 group (stage 2A): 316 (73.8%); T4a group (stage 2B): 78 patients (18.2%); and T4b group (stage 2C): 34 (8%). There were 187 (45.7%) post\u2010operative complications, 32 (7.5%) anastomotic leaks and eight (1.9%) 30\u2010day mortalities. Eighty patients (19.3%) died during the follow\u2010up. During the follow\u2010up period, 45 patients developed recurrence (all distant). Multivariate analysis identified age &gt;70\u2009years, American Society of Anesthesiologists grades III\u2013IV and male gender as factors associated with poor OS, while recurrence was higher in those aged over 70\u2009years and with stages 2B\u20132C disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Surgical morbidity in patients with stage 2 colonic cancer who have undergone curative surgery is high. Older and more co\u2010morbid patients have poorer OS. Stages 2B and 2C colon cancer patients have worse prognosis than those with stage 2A regarding recurrence. Future larger data sets are required to determine the role of transmural spread as a prognostic factor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.15876","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T09:50:32Z","timestamp":1586253032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post\u2010operative and oncological 3\u2010year follow\u2010up outcomes in stage 2 colonic cancer in the emergency and elective setting: a cohort study"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-2338","authenticated-orcid":false,"given":"Ricardo","family":"Frago","sequence":"first","affiliation":[{"name":"Department of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital University of Barcelona  Barcelona Spain"},{"name":"Digestive Tract Pathology IDIBELL  Barcelona 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