{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:39:48Z","timestamp":1792024788516,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acinic cell carcinoma (AcCC) is a rare malignant neoplasm of the salivary glands and generally considered to be a low\u2010grade tumour. Surgical treatment is often curative, but a more aggressive high\u2010grade variant has been associated with poorer survival and propensity for distant metastasis. No standard treatment guidelines exist and the approach to treatment is varied in the published series. The aim of this study is to present the experience of three major hospitals in Sydney, Australia, in treating AcCC of the salivary gland, with a focus on clinico\u2010pathological features of disease and their associations with survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult and paediatric cases of AcCC of the salivary gland during the time period 1979\u20132018 were retrospectively included. Demographic, clinico\u2010pathological, treatment and survival outcome data were extracted. Survival analysis was undertaken to assess the effect of clinical and pathological variables on overall and disease\u2010free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010two cases were reviewed (29 adult and three paediatric). Thirty tumours (93.8%) were parotid gland primary tumours. Mean overall and disease\u2010free survival was 17.0\u2009\u00b1\u20090.7 and 16.0\u2009\u00b1\u20090.9\u2009years, respectively. Features associated with poorer survival were cT staging &gt;1, presence of preoperative clinical facial nerve deficit and local recurrence. Positive margins were associated with recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data suggest that disease\u2010free and overall survival in AcCC of the salivary gland is excellent with surgery as the first\u2010line treatment. Poor survival outcomes are uncommon and may be associated with locally advanced disease in the presence of other well\u2010established high\u2010risk features.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.16421","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:44:56Z","timestamp":1605660296000},"page":"1233-1239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acinic cell carcinoma of the salivary gland in the adult and paediatric population: a survival analysis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-3448","authenticated-orcid":false,"given":"Anders","family":"Sideris","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery Prince of Wales Hospital  Sydney New South Wales Australia"},{"name":"ORL Head and Neck Research Group Prince of Wales Hospital  Sydney New 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