{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:38:24Z","timestamp":1747183104956,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Poorly differentiated adenocarcinomas and signet ring adenocarcinomas are aggressive histological subtypes of rectal cancer with a high incidence of occult peritoneal metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of aggressive histology of rectal cancer patients who underwent pre\u2010treatment surgical staging as part of ovarian transposition or ostomy creation for diversion at a single tertiary cancer centre between January 2014 and December 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 117 patients underwent surgical staging and were deemed non\u2010metastatic on imaging. Surgical staging led to the detection of metastasis in 29.9% of patients. This led to modification in treatment protocol in 20.5% and change in intent of therapy in 15.4%. The majority (80%) was found to have peritoneal disease with peritoneal carcinomatosis index &lt;17. Only T4 disease predicted the presence of metastasis on surgical staging with an odds ratio of 2.69 (<jats:italic>P<\/jats:italic> = 0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A significant proportion of patients with aggressive histology rectal cancers are upstaged after surgical staging. Further investigation of this tool for staging is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.16496","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T15:41:33Z","timestamp":1609342893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of surgical staging for aggressive histology rectal cancers: a retrospective review"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-0006","authenticated-orcid":false,"given":"Mufaddal","family":"Kazi","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgical Oncology Tata Memorial Hospital, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sri Siddhartha","family":"Nekkanti","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgical Oncology Tata Memorial Hospital, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitender","family":"Rohila","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgical Oncology Tata Memorial Hospital, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapnil","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgical Oncology Tata Memorial Hospital, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Sukumar","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgical Oncology Tata Memorial Hospital, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Desouza","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgical Oncology Tata Memorial Hospital, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avanish","family":"Saklani","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgical Oncology Tata Memorial Hospital, Homi Bhabha National Institute  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8679"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-017-0655-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2015.05.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0234-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-018-0803-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(00)80040-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1083-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v8.i12.819"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.369"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.1039"},{"key":"e_1_2_7_13_1","first-page":"287","article-title":"The value of staging laparoscopy in gastric cancer","volume":"30","author":"Machairas N","year":"2017","journal-title":"Ann. 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