{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:34:10Z","timestamp":1759336450184,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Histology represents the major source of information to define a usual interstitial pneumonia (UIP) pattern. However, the procedure is associated with significant morbidity and mortality. The aim of this study was to evaluate morbidity and mortality of surgical lung biopsy (SLB) in diagnosing UIP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing SLB with the ultimate diagnosis of UIP were studied. Clinical data concerning medical history, histology, pulmonary functions, radiology, length of hospital stay (LOS), morbidity and mortality status were retrospectively recruited from four hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included consecutive 93 patients with a SLB diagnosis of UIP. Mean age was 61\u2009\u00b1\u20098\u2009years, with one third of the patients were \u226565\u2009years. In 58 cases (62.4%), the biopsy was performed by video\u2010assisted thoracoscopic surgery, in 35 (37.7%) by limited thoracotomy. Eighty patients (86%) had possible UIP, 12 (12.9%) had inconsistent with UIP and one (1.1%) had UIP pattern on high\u2010resolution computed tomography. The mean LOS was 5.47\u2009\u00b1\u20093.16\u2009days. LOS was associated with smoking status (<jats:italic>P<\/jats:italic> = 0.024), type of biopsy (<jats:italic>P<\/jats:italic> = 0.00), 6\u2010min walk test (<jats:italic>P<\/jats:italic> = 0.00) and number of biopsy (<jats:italic>P<\/jats:italic> = 0.00). There was no in\u2010hospital and 30\u2010day mortality in our cohort, and 90\u2010day mortality rate was 1.1%. In seven patients (7.5%), we observed postoperative morbidities, predominantly prolonged air leakage (7.5% of all cases). Postoperative morbidity was only associated with the type of SLB. Patients with limited thoracotomy showed greater morbidity rates (17.1% versus 1.7%, <jats:italic>P<\/jats:italic> = 0.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SLB is a relatively safe procedure in the diagnosis of UIP and can be performed in suitable patients with suspected UIP\/idiopathic pulmonary fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.16681","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T07:15:37Z","timestamp":1614582937000},"page":"298-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Morbidity and mortality of surgical lung biopsy in the diagnosis of usual interstitial pneumonia"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-3502","authenticated-orcid":false,"given":"Aykut","family":"Cilli","sequence":"first","affiliation":[{"name":"Department of Respiratory Diseases Akdeniz University Hospital  Dumlup\u0131nar Bulvar\u0131 Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celalettin","family":"Kocaturk","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Liv Hospital Ulus, Istinye University  Ahmet Adnan Saygun Street Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1141-5637","authenticated-orcid":false,"given":"Kemal C.","family":"Tertemiz","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Dokuz Eylul University Hospital  Fahrettin Altay Street Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem E.","family":"Kalafat","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Ayd\u0131n University Hospital  Akasya Sok Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Hanta","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Cukurova University Hospital  Balcali Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-0415","authenticated-orcid":false,"given":"Ayse","family":"Odemis","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Akdeniz University Hospital  Dumlup\u0131nar Bulvar\u0131 Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Sevinc","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases Dokuz Eylul University Hospital  Fahrettin Altay Street Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levent","family":"Dertsiz","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Akdeniz University Hospital  Dumlup\u0131nar Bulvar\u0131 Antalya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neslihan","family":"Akanil Fener","sequence":"additional","affiliation":[{"name":"Department of Pathology Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital  Belgrat Kap\u0131 yolu Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,28]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"285","article-title":"Clinical practice guideline summary for practicing clinicians: diagnosis of idiopathic pulmonary fibrosis","volume":"16","author":"Thomson CC","year":"2018","journal-title":"Ann. 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