{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T12:00:25Z","timestamp":1769688025176,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anaemia is a common manifestation of colorectal cancer (CRC). However, appropriate workup prior to surgery and the effect of anaemia on outcomes have not been well defined. This study aimed to describe preoperative anaemia incidence, investigations performed, treatment and associated complications in a CRC surgical population at a single large tertiary institution in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who received surgery with curative intent for CRC between 2012 and 2017 were identified from a prospectively maintained database. Demographic and clinical outcome data were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 754 patients with CRC were included. Anaemia was found in 350 (46.4%) patients, of which 124 (35.4%) were microcytic, 20 (5.7%) were macrocytic and 206 (58.9%) were normocytic. Older patients were more likely to have anaemia (mean age 70.28\u2009years, standard deviation (SD) 12.98 versus 64.74\u2009years, SD 11.74). Only 89 patients (25.4%) were tested for iron deficiency, and of these, 76 (85.4%) were found to be iron deficient and 42 (47.7%) had low ferritin. Preoperative anaemia was associated with a higher incidence of postoperative complications (adjusted odds ratio (OR) 1.46, 95%, CI 1.04\u20132.05; <jats:italic>P<\/jats:italic>\u00a0=\u20090.03) and a longer length of stay (LOS; average 1.8\u2009days; 95% CI 0.3\u20133.3\u2009days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A significant proportion of CRC patients had anaemia and the majority were normocytic. Only a small number of anaemic patients were tested for iron deficiency. Preoperative anaemia had an adverse effect on LOS and postoperative complications. The evaluation of anaemic patients is essential in CRC patients undergoing surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.16774","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T08:48:10Z","timestamp":1618390090000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anaemia and its impact on colorectal cancer patients: how can we better optimize surgical outcomes?"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6868-1816","authenticated-orcid":false,"given":"Vanessa","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Deftereos","sequence":"additional","affiliation":[{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"},{"name":"Department of Nutrition and Dietetics Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bilkis","family":"Mahbub","sequence":"additional","affiliation":[{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Simons","sequence":"additional","affiliation":[{"name":"School of Population and Global Health University of Melbourne  Melbourne Victoria Australia"},{"name":"Office for Research Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Faragher","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T. F.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin M.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Western Health  Melbourne Victoria Australia"},{"name":"Department of Surgery Western Precinct, University of Melbourne  Melbourne Victoria Australia"},{"name":"Chronic Disease Alliance Western Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Bowel Cancer","author":"Cancer Council Australia"},{"key":"e_1_2_8_3_1","volume-title":"Cancer in Victoria: Statistics and Trends 2017","author":"Thursfield V","year":"2017"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.14425"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-016-2678-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10328"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19572-y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604165"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-018-3211-7"},{"key":"e_1_2_8_10_1","unstructured":"MurphyE HeriotA BarclayK et al.Perioperative anaemia management. Clinical practice guidelines for the prevention early detection and management of colorectal cancer. Cancer Council Australia.2017."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31825b35d5"},{"key":"e_1_2_8_12_1","unstructured":"National Blood Authority Australia.Preoperative Anaemia Identification Assessment and Management: A Case Study. Guidance for Australian Health Providers 2014. [Cited Aug 2021] Available from URL:https:\/\/www.blood.gov.au\/system\/files\/documents\/preoperative-anaemia-identification-assessment-and-management-case-study%20grey%20cover%20v4.pdf"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1983.tb02430.x"},{"key":"e_1_2_8_14_1","first-page":"138","article-title":"Clinico\u2010pathological and oncological differences between right and left\u2010sided colon cancer (stage I\u2010III): analysis of 950 cases","volume":"110","author":"Cienfuegos JA","year":"2018","journal-title":"Rev. Esp. Enferm. 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