{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:43:13Z","timestamp":1792651393656,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009727","name":"Hospital Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to describe the clinical outcomes of total pancreatectomy with islet autotransplantation (TP\u2010IAT) in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals selected for TP\u2010IAT surgery according to the Minnesota Criteria (Appendix) without evidence of diabetes were evaluated including time to transplantation from pancreatectomy, islet numbers infused and post\u2010transplantation HbA1c, C\u2010peptide, total daily insulin and analgesic requirement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen individuals underwent TP\u2010IAT from Australia and New Zealand between 2010 and 2020. Two recipients are deceased. The median islet equivalents\/kg infused was 4244 (interquartile range (IQR) 2290\u20137300). The median C\u2010peptide 1\u2009month post\u2010TP\u2010IAT was 384 (IQR 210\u2013579) pmol\/L and at median 29.5 (IQR 14.5\u201346.5) months from transplant was 395 (IQR 139\u2013862) pmol\/L. Insulin independence was achieved in eight of 15 (53.3%) surviving recipients. A higher islet equivalents transplanted was most strongly associated with the likelihood of insulin independence (<jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.05). Of the 15 surviving recipients, 14 demonstrated substantial reduction in analgesic requirement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The TP\u2010IAT programme in Australia has been a successful new therapy for the management of individuals with chronic pancreatitis including hereditary forms refractory to medical treatment to improve pain management with 50% insulin independence rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.16853","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T14:25:38Z","timestamp":1620397538000},"page":"2663-2668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Australian experience with total pancreatectomy with islet autotransplantation to treat chronic pancreatitis"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7326-286X","authenticated-orcid":false,"given":"Tristan J.","family":"Bampton","sequence":"first","affiliation":[{"name":"Faculty of Health and Medical Sciences, The University of Adelaide  Adelaide South Australia Australia"},{"name":"The Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Jane","family":"Holmes\u2010Walker","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Westmead Hospital  Sydney New South Wales Australia"},{"name":"Westmead Institute for Medical Research  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris J.","family":"Drogemuller","sequence":"additional","affiliation":[{"name":"The Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Radford","sequence":"additional","affiliation":[{"name":"The Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Anderson","sequence":"additional","affiliation":[{"name":"Westmead Institute for Medical Research  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Etherton","sequence":"additional","affiliation":[{"name":"The Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Russell","sequence":"additional","affiliation":[{"name":"The Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Torpy","sequence":"additional","affiliation":[{"name":"The Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Couper","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. L. T.","family":"Couper","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Women's and Children's Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Macintyre","sequence":"additional","affiliation":[{"name":"The Central and Northern Renal and Transplantation Service, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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E.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Islet biology, St Vincent's Institute  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle J.","family":"Palmer","sequence":"additional","affiliation":[{"name":"School of Public Health The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghao","family":"Wu","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medical Sciences, The University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha M.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Westmead Institute for Medical Research  Sydney New South Wales Australia"},{"name":"Department of Renal Medicine Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Westmead Institute for Medical Research  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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