{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T16:17:31Z","timestamp":1785773851280,"version":"3.56.0"},"reference-count":28,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903235"],"award-info":[{"award-number":["81903235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ21H110001"],"award-info":[{"award-number":["LQ21H110001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20180145"],"award-info":[{"award-number":["Y20180145"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To determine risk factors for intestinal necrosis in intussusception cases among children with failed non\u2010surgical reduction for intussusception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Totally, 540 hospitalized individuals with unsuccessful air\u2010enema reduction in our hospital between November 2010 and November 2020 were assessed in this retrospective study. The 540 intussusception cases were divided into the intestinal necrosis and non\u2010intestinal necrosis groups. Haemostatic parameters, demographic and clinical features were assessed. Predictors of intestinal necrosis were examined by univariable and multivariable logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 540 patients included, 113 showed intestinal necrosis. This intestinal necrosis group had a longer duration of symptom or length of illness, younger ages, higher platelet counts, fibrinogen amounts and <jats:sc>d<\/jats:sc>\u2010dimer levels (all <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000) compared with the non\u2010intestinal necrosis group. Multivariable analysis revealed that duration of symptom (odds ratio (OR) 1.12; 95% confidence interval (CI) 1.16\u20131.23, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000), fibrinogen (OR 1.26; 95% CI 1.10\u20131.31, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.010) and <jats:sc>d<\/jats:sc>\u2010dimer (OR 2.07; 95% CI 1.91\u20132.28, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.000) independently predicted intestinal necrosis in individuals undergoing surgical reduction for intussusception. Receiver operating characteristic curve analysis showed that <jats:sc>d<\/jats:sc>\u2010dimer amounts had the largest area under the curve for predicting intestinal necrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>On admission, long duration of symptom, high fibrinogen and <jats:sc>d<\/jats:sc>\u2010dimer levels are critical risk factors for intestinal necrosis development in children with unsuccessful non\u2010surgical reduction. <jats:sc>d<\/jats:sc>\u2010Dimer levels have the best predictive value for intestinal necrosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.16854","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T04:38:10Z","timestamp":1619584690000},"page":"1485-1490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Haemostatic indexes for predicting intestinal necrosis in children with intussusception"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-6752","authenticated-orcid":false,"given":"Hui\u2010Ya","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-9860","authenticated-orcid":false,"given":"Xiao\u2010Kun","family":"Lin","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Kun","family":"Guo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Zhou","family":"Bao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Xiu","family":"Lin","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong\u2010Rong","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Zhong","family":"Huang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital and Yuying Children's Hospital Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz028"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068482"},{"key":"e_1_2_8_4_1","first-page":"CD006476","article-title":"Management for intussusception in children","volume":"6","author":"Gluckman S","year":"2017","journal-title":"Cochrane Database Syst. 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