{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:27:36Z","timestamp":1790162856374,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009287","name":"NSW Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009287","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic limb\u2010threatening ischaemia (CLTI) carries significant amputation and mortality risks. Australian population\u2010based outcomes for CLTI are inadequately known. This study aimed to distinguish factors associated with outcomes in the first 2\u2009years after CLTI surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By linking routinely collected health administrative and mortality data from New South Wales, this population\u2010based cohort study identified patients with ischaemic rest pain, gangrene or ulceration undergoing vascular surgery in public hospitals between 2010 and 2012. The primary outcome was 2\u2010year amputation\u2010free survival (AFS), and secondary outcomes included readmission and reoperation rates. Multivariable regression analysis identified prognostic factors adjusted for patient, hospital and geographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Primary CLTI surgery was performed on 4898 patients. Almost half the cohort had minor amputations without concurrent revascularization (2398, 49%), and the remaining patients had open (652, 13%) or endovascular (1848, 38%) surgery. At 2\u2010years, the AFS rate was 72%. Significant disparity was seen between age groups, with the 2\u2010year AFS 71% in patients aged 75\u2009years or older, compared to 95% in patients aged less than 75\u2009years (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u20090.001). Place of residence or hospital training status did not significantly influence AFS or readmission, but non\u2010training hospitals had higher rates of reoperation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This population\u2010based cohort study demonstrated variable outcomes for patients with CLTI, particularly with respect to older age, admission acuity and comorbidity. Results may guide service improvements however further research is needed into how population\u2010wide health initiatives can address age\u2010related disparities in CLTI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.16886","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:42:56Z","timestamp":1619570576000},"page":"1211-1219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Variation in treatment and outcomes for patients with chronic limb\u2010threatening ischaemia in New South Wales, Australia"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-7845","authenticated-orcid":false,"given":"Oh Sung","family":"Choy","sequence":"first","affiliation":[{"name":"Concord Clinical School, Faculty of Medicine and Health, The University of Sydney, Concord Institute of Academic Surgery Concord Repatriation General Hospital Nepean Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Manewell","sequence":"additional","affiliation":[{"name":"Podiatry Department Concord Repatriation General Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8019-9827","authenticated-orcid":false,"given":"Saissan","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Concord Clinical School, Faculty of Medicine and Health, The University of Sydney, Concord Institute of Academic Surgery, Vascular Department Concord Repatriation General Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-6213","authenticated-orcid":false,"given":"Sarah J.","family":"Aitken","sequence":"additional","affiliation":[{"name":"Concord Clinical School, Faculty of Medicine and Health, The University of Sydney, Concord Institute of Academic Surgery, Vascular Department Concord Repatriation General Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2019.05.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S209241"},{"key":"e_1_2_9_4_1","volume-title":"Diabetes Complications","author":"Australian Institute of Health and Welfare (AIHW)","year":"2020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2019.05.055"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.13623"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.04.048"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.10.026"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.005531"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.01.061"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004995"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007425"},{"key":"e_1_2_9_13_1","unstructured":"Australian Consortium for Classification Development.The International Statistical Classification of Diseases and Releated Health Problems 10th revision Australian modification (ICD\u201010\u2010AM\/ACHI\/ACS)(10th edn).Indepedent Hospital Pricing Authority: Darlinghurst2017."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.54866"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-6405.12731"},{"key":"e_1_2_9_16_1","unstructured":"Australian Bureau of Statistics. 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