{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:40:15Z","timestamp":1747183215864,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenal vein sampling (AVS) is integral to identifying surgically remediable unilateral primary aldosteronism (PA). However, right adrenal vein (AV) cannulation can be challenging, limiting its success. Intra\u2010procedural cortisol assays can improve the reliability of AVS. The aim of this study was to validate the use of semi\u2010quantitative cortisol estimates obtained utilizing a quick cortisol assay (QCA) during AVS procedures at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of results of AVS procedures before and after the introduction of the QCA. Twenty\u2010three AVS procedures were performed with the provisional success determined by intra\u2010procedural QCA. Successful AV cannulation was defined by an AV to peripheral vein cortisol ratio\u2009\u2265\u20094.0 (the selectivity index) from laboratory measurements. The control cohort consisted of 23 consecutive procedures prior to introduction of the QCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>QCA correctly predicted all AV cannulation attempts. Successful bilateral AV cannulation increased from 52% to 91% of procedures when performed with the QCA (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and adequate cannulation of the right AV increased from 61% to 91% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). There was no increase in procedural time, number of AV cannulation or sampling attempts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Point\u2010of\u2010care, semi\u2010quantitative cortisol estimates can be performed accurately during AVS with QCA, facilitating improvements in AVS success rates without increasing procedural time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17352","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T05:00:57Z","timestamp":1637557257000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Utility of semi\u2010quantitative quick cortisol assay with low\u2010dose adrenocorticotropic hormone infusion adrenal vein sampling"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-497X","authenticated-orcid":false,"given":"Matthew P.","family":"Sawyer","sequence":"first","affiliation":[{"name":"Department of Endocrinology &amp; Diabetes St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric X. 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