{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:41:38Z","timestamp":1784292098503,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Posterior urethral valve (PUV) is the most common congenital cause of bladder outflow obstruction in male infants. Despite timely treatment, renal damage can still occur in the long\u2010term leading to chronic kidney disease (CKD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of all PUV patients in a single tertiary institution between April 1998 and July 2019 was conducted to analyze their presentations, management and outcomes. Long\u2010term renal function, radiologic scans and somatic growth were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 16 patients were included in this study. Two patients who defaulted all follow\u2010ups were excluded. Seven patients (43.7%) presented in the antenatal period; four patients (25%) presented in the neonatal period and five patients (31.3%) presented in the post\u2010neonatal period. Primary transurethral fulguration of valves was done in 13 patients, while three had vesicostomies as the primary procedure. Three patients had associated anterior urethral valves (AUV), which were treated endoscopically. Nine boys had additional procedures for diversion and undiversion, VUR, non\u2010functioning kidney and clean intermittent catheterization. Ten patients had urodynamic studies performed, of which eight patients received anticholinergic therapy. Eleven patients had DMSA scans, of which three patients had a normal study and eight patients showed unilateral reduced function. Four patients were diagnosed with CKD on long\u2010term follow\u2010up duration over 5\u2009years. All patients were shown to have good somatic growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with PUV can suffer from complications despite primary treatment. In our small cohort, a quarter of our patients developed CKD on follow\u2010up. Thus, patients need long\u2010term follow\u2010up to optimize bladder and renal function.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17445","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T10:03:23Z","timestamp":1643018603000},"page":"1159-1164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcome of boys with posterior urethral valves from a single tertiary hospital in Singapore"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-5548","authenticated-orcid":false,"given":"Ming Tow","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Ern\u2010Hwei","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hong","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Paediatrics KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te\u2010Lu","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin Yin","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan Laksmi","family":"Narasimhan","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette Sundfor","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/351067"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000660604.20951.09"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/9.3.174"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/BJUIw-2012-026-web"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.74434"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2009.09.001"},{"key":"e_1_2_9_8_1","first-page":"708","article-title":"Balpinder kaur: anterior urethral valves","volume":"42","author":"Narasimhan KL","year":"2005","journal-title":"Indian Pediatr."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64375-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.09.062"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-019-04280-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3815-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.04.049"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.02.2968"},{"key":"e_1_2_9_15_1","first-page":"2","article-title":"Persistent ureteral dilatation following valve ablation","volume":"5","author":"Mitchell ME","year":"1982","journal-title":"Dialogue Pediatr Urol."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65453-5"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2011.08.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-27843-3_71-1"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/UA.UA_112_19"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3046.2001.00003.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04350419"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/01.JU.0000614688.47109.ee","article-title":"Re: a clinical predictive model of chronic kidney disease in children with posterior urethral valves","volume":"203","author":"Canning D","year":"2020","journal-title":"J. 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