{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:47:41Z","timestamp":1784630861228,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,28]],"date-time":"2022-03-28T00:00:00Z","timestamp":1648425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is still a search for a standard method of therapy for high anal fistulas. The aim of this trial was a comparison between a modified two stage minimally invasive procedure, consisting of loose\u2010seton placement with the subsequent application of platelet rich plasma with mucosal advancement flap for the treatment of high transsphincteric anal fistulas of crypto\u2010glandular origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was designed as a prospective, randomized trial including 96 patients. Curettage of fistulous tracts, and loose\u2010seton placement was performed in those patients with active inflammation, and if the diameter of a fistulous tract exceeded 3\u2009mm. Afterwards, the patients were randomly assigned to either the PRP group or MAF group, consisting of 49 patients, and 47 patients, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant statistical difference (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.152) between both investigated groups of patients regarding closure of fistulas since it was achieved in 35 (71.43%) patients from group I, compared to 27 (57.45%) patients from group II. The diameter of fistulous tracts below 4\u2009mm exerted a significant impact (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) on the healing process after PRP application because fistulas with the narrow tracts were closed in 34 (87.18%) patients, whereas a wider fistula was healed in 1 (10%) patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The local application of PRP in high, unbranched, and with narrow tracts trans\u2010sphincteric anal fistulas of crypto\u2010glandular origin, following loose\u2010seton drainage is an effective, simple, and a safe method of therapy with a low rate of morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17656","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T05:59:43Z","timestamp":1648533583000},"page":"1137-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison between application of platelet rich plasma and mucosal advancement flap in patients with high transsphincteric anal fistulas: a randomized control trial"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7236-0409","authenticated-orcid":false,"given":"Jacek","family":"Hermann","sequence":"first","affiliation":[{"name":"Department of General, and Endocrine Surgery, and Gastroenterologic Oncology Pozna\u0144 University of Medical Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Cwali\u0144ski","sequence":"additional","affiliation":[{"name":"Department of General, and Endocrine Surgery, and Gastroenterologic Oncology Pozna\u0144 University of Medical Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Banasiewicz","sequence":"additional","affiliation":[{"name":"Department of General, and Endocrine Surgery, and Gastroenterologic Oncology Pozna\u0144 University of Medical Sciences  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ko\u0142odziejczak","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics and Computer Science Adam Mickiewicz University  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2016.02.002"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-005-0072-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.05.205"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-009-0826-6"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-010-0993-7"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-018-3155-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-006-0172-z"},{"key":"e_1_2_10_9_1","first-page":"123","article-title":"Using autologous platelet\u2010rich plasma for the treatment of complex fistulas","volume":"108","author":"Moreno\u2010Serrano A","year":"2016","journal-title":"Rev. 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