{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T05:06:19Z","timestamp":1748063179387,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study is to determine the prevalence of incidental radiological findings detected on SPECT\/CT performed as part of pre\u2010operative lymphoscintigraphy for sentinel lymph node biopsy (SLNB) in patients undergoing breast cancer surgery and development of a modified classification to workup these lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective audit was performed of all SPECT\/CT performed in combination with lymphoscintigrams in breast cancer patients presenting with clinically node negative axillae and operated on by breast surgeons at the Westmead Breast Cancer Institute over a 12\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and nineteen patients were included in the study. In 149 patients (35.6%), there was a total of 205 incidental findings. The most common findings were, pulmonary abnormalities (38.5%), abdominal findings (27.8%), thyroid nodules (14.6%), cardiac abnormalities (10.7%) and others (8.3%). Using our proposed Westmead SPECT\/CT incidental findings (WSIF) classification, 7.8% were known, 17.6% were major findings, 48.3% were minor findings, 15.1% were minimal findings and 11.2% were equivocal findings. 17.6% (<jats:italic>n<\/jats:italic>\u00a0=\u200936) underwent further workup and investigation and 3.4% of patients (<jats:italic>n<\/jats:italic>\u00a0=\u20095) required therapeutic intervention, including chemotherapy for primary lung cancer(<jats:italic>n<\/jats:italic>\u00a0=\u20091) and surgeries (thoracotomy, <jats:italic>n<\/jats:italic>\u00a0=\u20091; thyroidectomy, <jats:italic>n<\/jats:italic>\u00a0=\u20092; colonoscopy, <jats:italic>n<\/jats:italic>\u00a0=\u20091). 93.8% (<jats:italic>n<\/jats:italic>\u00a0=\u2009393) had at least one SLN mapped, most commonly located in Level 1 of the axilla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidental findings on SPECT\/CT in combination with lymphoscintigraphy is within the range of previous studies (27.3\u201359.5%). A small proportion of patients required significant major interventions (3.4%). We propose that all incidental findings should be assessed according to our WSIF classification to aid in triaging need for further investigation and management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17659","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T13:05:47Z","timestamp":1648731947000},"page":"1434-1439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Incidental findings on single\u2010photon emission computed tomography\/computed tomography (<scp>SPECT<\/scp>\/<scp>CT)<\/scp> lymphoscintigraphy in breast cancer: the proposed Westmead <scp>SPECT<\/scp>\/<scp>CT<\/scp> incidental findings classification"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-6717","authenticated-orcid":false,"given":"Gaik Si","family":"Quah","sequence":"first","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney, Westmead Clinical school  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"French","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney, Westmead Clinical school  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damon J.","family":"Gordon","sequence":"additional","affiliation":[{"name":"University of Sydney, Westmead Clinical school  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laximi Y.","family":"Juvarkar","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital  Westmead New South Wales Australia"},{"name":"Department of Radiology Westmead Hospital  Westmead New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Meybodi","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney, Westmead Clinical school  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Hsu","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney, Westmead Clinical school  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6686-9898","authenticated-orcid":false,"given":"Elisabeth","family":"Elder","sequence":"additional","affiliation":[{"name":"Westmead Breast Cancer Institute, Westmead Hospital  Westmead New South Wales Australia"},{"name":"University of Sydney, Westmead Clinical school  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnmt.116.174557"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04404-6"},{"key":"e_1_2_8_4_1","first-page":"1312","article-title":"Clinically significant abnormal findings on the \"nondiagnostic\" CT portion of low\u2010amperage\u2010CT attenuation\u2010corrected myocardial perfusion SPECT\/CT studies","volume":"47","author":"Goetze S","year":"2006","journal-title":"J. Nucl. Med."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjz008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000227362.33910.7a"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20130701"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1754-9485.12254"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-018-1257-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017161659"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.17659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.17659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.17659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T12:03:26Z","timestamp":1692878606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.17659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/ans.17659"],"URL":"https:\/\/doi.org\/10.1111\/ans.17659","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"type":"print","value":"1445-1433"},{"type":"electronic","value":"1445-2197"}],"subject":[],"published":{"date-parts":[[2022,3,31]]},"assertion":[{"value":"2021-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}