{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:41:25Z","timestamp":1788799285103,"version":"build-2803163510"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T00:00:00Z","timestamp":1648944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The COVID\u201019 pandemic has had a significant impact on global surgery. In particular, deleterious effects of SARS\u2010CoV\u20102 infection on the heart and cardiovascular system have been described. To inform surgical patients, we performed a systematic review and meta\u2010analysis aiming to characterize outcomes of COVID\u201019 positive patients undergoing cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study protocol was registered with PROSPERO (CRD42021228533) and conformed with PRISMA 2020 and MOOSE guidelines. PubMed, Ovid MEDLINE and Web of Science were searched between 1 January 2019 to 24 February 2022 for studies reporting outcomes on COVID\u201019 positive patients undergoing cardiac surgery. Study screening, data extraction and risk of bias assessment were conducted in duplicate. Meta\u2010analysis was conducted using a random\u2010effects model where at least two studies had sufficient data for that variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Searches identified 4223 articles of which 18 studies were included with a total 44 patients undergoing cardiac surgery. Within these studies, 12 (66.7%) reported populations undergoing coronary artery bypass graft (CABG) surgery, three (16.7%) aortic valve replacements (AVR) and three (16.7%) aortic dissection repairs. Overall mean postoperative length of ICU stay was 3.39 (95% confidence interval (CI): 0.38, 6.39) and mean postoperative length of hospital stay was 17.88 (95% CI: 14.57, 21.19).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis investigated studies of limited quality which characterized cardiac surgery in COVID\u201019 positive patients and demonstrates that these patients have poor outcomes. Further issues to be explored are effects of COVID\u201019 on decision\u2010making in cardiac surgery, and effects of COVID\u201019 on the cardiovascular system at a cellular level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.17667","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T02:19:04Z","timestamp":1649038744000},"page":"1007-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cardiac surgery on patients with\n                    <scp>COVID<\/scp>\n                    \u201019: a systematic review and\n                    <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-0378","authenticated-orcid":false,"given":"Aashray K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Surgery University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Cardiothoracic Surgery Royal Adelaide Hospital  Adelaide Australia"},{"name":"University of Adelaide, Discipline of Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair","family":"Leslie","sequence":"additional","affiliation":[{"name":"University of Adelaide, Discipline of Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2959-4554","authenticated-orcid":false,"given":"Joseph N.","family":"Hewitt","sequence":"additional","affiliation":[{"name":"University of Adelaide, Discipline of Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-3840","authenticated-orcid":false,"given":"Joshua G.","family":"Kovoor","sequence":"additional","affiliation":[{"name":"University of Adelaide, Discipline of Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8075-7852","authenticated-orcid":false,"given":"Christopher D.","family":"Ovenden","sequence":"additional","affiliation":[{"name":"University of Adelaide, Discipline of Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Edwards","sequence":"additional","affiliation":[{"name":"Adelaide Health Technology Assessment, School of Public Health University of Adelaide  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C. 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