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This study aims to explore the predictors of CR\u2010POPF after PD, including net parenchymal thickness (NPT) of pancreatic neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The consecutive patients who underwent PD at a tertiary hospital were retrospectively reviewed. Univariate and multivariate analyses were conducted on the perioperative data, which was mainly extracted from the objective data, containing the results from the laboratory tests and the imaging examination. NPT refers to the total thickness of pancreatic gland excluding main pancreatic duct (MPD) at the CT film.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Univariate analyses showed that total serum bilirubin (TBiL) and albumin (ALB) levels, MPD size and NPT were significantly different between the patients with and without CR\u2010POPF. The white blood cell count, the rate of intra\u2010abdominal infection (IAI) and the postoperative length of hospital stay (LOS) were associated with the incidence of CR\u2010POPF. The proportion of patients with pancreatic adenocarcinoma or chronic pancreatitis was significantly lower in the CR\u2010POPF group than in the non\u2010CR\u2010POPF group. Multivariate analyses manifested that ALB \u226435\u2009g\/L and NPT &gt;10\u2009mm were two of the independent risk factors for CR\u2010POPF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative ALB \u226435\u2009g\/L and NPT &gt;\u200910\u2009mm were both the independent predictors of CR\u2010POPF. CR\u2010POPF was associated with the higher IAI rate and the extended LOS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17673","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T07:43:14Z","timestamp":1649317394000},"page":"1097-1104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The net parenchymal thickness predicts pancreatic fistula after pancreaticoduodenectomy: a retrospective cohort study of objective data"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-7961","authenticated-orcid":false,"given":"Sun\u2010Bing","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine Zhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases  Hangzhou 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