{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:48:01Z","timestamp":1791110881553,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of elderly patients with resectable colorectal peritoneal metastases (CRPM) is increasing. This study aimed to compare short and long\u2010term outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for CRPM in patients above and below 70\u2009years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective, 10\u2010year analysis of 90\u2010day major morbidity and mortality, and long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two (21.3%) of 150 consecutive patients who underwent CRS and HIPEC during the study period were aged 70 and older. PCI (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), perioperative chemotherapy use (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and organ resections (rectum <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04, diaphragm <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) were less in the over 70 group. There was no significant differences in major morbidity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.19) and mortality (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.32). There was also no difference in 5\u2010year overall survival (OS) (\u226570: 26% vs. &lt;70: 39%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.68) and disease\u2010free survival (DFS) (\u226570: 25% vs. &lt;70: 14%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.22). Age above 70 was not independently associated with worse OS (HR 1.55, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.20) and DFS (HR 1.07, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.81).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The surgical management of CRPM appears safe and feasible in this elderly population. Appropriate selection of elderly patients for such radical intervention is reinforced by the comparable survival with those under 70.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17761","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T09:18:35Z","timestamp":1652087915000},"page":"2192-2198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases in an elderly population: outcomes from a single centre"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-8343","authenticated-orcid":false,"given":"Michael P.","family":"Flood","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne 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