{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:26:28Z","timestamp":1760077588704,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:00:00Z","timestamp":1653868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of adenocarcinoma of the distal oesophagus (DO) and gastro\u2010oesophageal junction (GOJ) are increasing. They may represent differing disease processes. This study aimed to assess clinicopathological and survival differences between patients with DO and GOJ adenocarcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were extracted from a prospective single\u2010surgeon database of consecutive patients undergoing an open Ivor\u2010Lewis oesophagectomy for oesophageal adenocarcinoma (distal oesophagus, Siewert type I and II). Differences in clinicopathological characteristics and survival were evaluated and prognostic factors examined using univariate and multivariate survival analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The data were available for 234 patients who underwent an oesophagectomy between 1992 and 2019. DO tumours had higher rates of Barrett's oesophagus (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), presented with lower tumour stage (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02) and were more likely to be associated with fewer lymph nodes resected (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) than GOJ tumours. The median overall survival for distal oesophageal tumours was 29.2\u00a0months, while gastro\u2010oesophageal tumours was 38.6\u00a0months. Kaplan Meier analysis did not show a difference in overall survival between the two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.08). However, when adjusted for potential confounders, GOJ tumours were associated with a reduced adjusted hazard of death (adjusted HR 0.58, 95% CI 0.36\u20130.92, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.022) compared with DO tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that GOJ cancers have different clinicopathological characteristics and improved survival compared to DO tumours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.17828","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T09:21:06Z","timestamp":1653902466000},"page":"2137-2142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathologic and survival differences between adenocarcinoma of the distal oesophagus and gastro\u2010oesophageal junction"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9611-6109","authenticated-orcid":false,"given":"Steven Ronald","family":"Paredes","sequence":"first","affiliation":[{"name":"School of Medicine University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6141-4504","authenticated-orcid":false,"given":"Ngar Lok Joshua","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-8748","authenticated-orcid":false,"given":"Oleksandr","family":"Khoma","sequence":"additional","affiliation":[{"name":"School of Medicine University of Notre Dame, Sydney  New South Wales Australia"},{"name":"Upper GI Department Concord Repatriation General Hospital  Concord New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-1204","authenticated-orcid":false,"given":"Jin\u2010soo","family":"Park","sequence":"additional","affiliation":[{"name":"School of Medicine University of Notre Dame, Sydney  New South Wales Australia"},{"name":"Upper GI Department Concord Repatriation General Hospital  Concord New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-912X","authenticated-orcid":false,"given":"Catherine","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Surgery Strathfield Private Hospital  Strathfield New South Wales Australia"},{"name":"Department of Surgery Sydney Adventist Hospital  Wahroonga New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4184-3330","authenticated-orcid":false,"given":"Hans","family":"Van der Wall","sequence":"additional","affiliation":[{"name":"School of Medicine University of Notre Dame, Sydney  New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9052-2061","authenticated-orcid":false,"given":"Gregory Leighton","family":"Falk","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sydney  Sydney New South Wales Australia"},{"name":"School of Medicine University of Notre Dame, Sydney  New South Wales Australia"},{"name":"Upper GI Department Concord Repatriation General Hospital  Concord New South Wales Australia"},{"name":"Department of Surgery Strathfield Private Hospital  Strathfield New South Wales Australia"},{"name":"Department of Surgery Sydney Adventist Hospital  Wahroonga New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-1159"},{"key":"e_1_2_8_3_1","first-page":"13","article-title":"Overview of gastroesophageal junction cancers. 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