{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:07:41Z","timestamp":1747908461634,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Potential organ donors with primary brain tumours (PBT) frequently donate, however some may be declined due to uncertainty about tumour classification or transmission risk to transplant recipients. We sought to describe transmission risk and donation outcome of potential donors with PBT, including identifying missed opportunities for transplantation, and any PBT transmission events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a population\u2010based cohort study in NSW of all potential donors 2010\u20132015. PBT potential donors were characterized according to tumour grade and transmission risk, and whether they donated organs. Data linkage was used to determine agreement of risk assessment of potential donors to that in the Biovigilance Register, and to identify any PBT transmissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2957 potential donors, 76 (3%) had PBTs. There was agreement of risk assessment in 44 (58%) cases. PBT potential donors had fewer comorbidities (1.6 vs. 2.1,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) than non\u2010PBT potential donors. Forty\u2010eight (63%) potential donors were declined for non\u2010PBT reasons, 18 (24%) were declined because of perceived PBT transmission risk and 10 (13%) donated. All PBT donors had WHO\u2010I or \u2010II tumours, and none had a ventriculo\u2010pertioneal shunt. No transmission events occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Donors with WHO\u2010I\/II PBT appear to have minimal risk of tumour transmission in solid organ transplantation; it is reassuring that no PBT transmission occurred. There is evidence of risk aversion to referrals with WHO\u2010III\/IV tumours. There exists opportunity to improve potential donor risk assessment at the time of referral using integrated data sets, and to increase organ donation and transplantation rates through greater utilization of PBT referrals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18037","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T14:49:03Z","timestamp":1663771743000},"page":"2996-3003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Potential organ donors with primary brain tumours: missed opportunities for donation and transplantation identified in Australian cohort study 2010\u20132015"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-7272","authenticated-orcid":false,"given":"Imogen K.","family":"Thomson","sequence":"first","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6077-0862","authenticated-orcid":false,"given":"James","family":"Hedley","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda M.","family":"Rosales","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Wyburn","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia"},{"name":"Renal Department Royal Prince Alfred Hospital Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"O'Leary","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Royal Prince Alfred Hospital Camperdown New South Wales Australia"},{"name":"New South Wales Organ and Tissue Donation Service Kogarah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela C.","family":"Webster","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health, Faculty of Medicine and Health University of Sydney Camperdown New South Wales Australia"},{"name":"Centre for Transplant and Renal Research Westmead Hospital Westmead New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Human Resources and Services Administration.Organ donation statistics. 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