{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:15:00Z","timestamp":1792818900889,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T00:00:00Z","timestamp":1663804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pseudomyxoma peritonei (PMP) is a clinically malignant tumour syndrome mainly derived from mucin\u2010producing appendiceal tumours. This study aimed to explore the effect of preoperative systemic chemotherapy (PSC) before cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) on the safety and postoperative survival in patients with appendiceal PMP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis including consecutive patients with PMP undergoing primary surgery between January, 2008 and December, 2019 in Aerospace Center Hospital. The clinical data and postoperative survival were compared between PSC group and non\u2010PSC group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven hundred and fifty patients were included in the study. Significant differences were found between PSC group and non\u2010PSC group on clinicopathological data and perioperative outcomes and the independent risk factor of serious complications was blood loss &gt;1000\u2009mL (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026). Shorter median overall survival (OS) was found (42\u2009months, 95% CI 31.9\u201352.1) in PSC group than that (67\u2009months 95% CI 44.5\u201389.5) in non\u2010PSC group. In the stratified study with PCI\u2009&lt;\u200920, CC 0\/1 and low\u2010grade pathological subtype, the OS from non\u2010PSC group was significantly better than that in PSC group (log rank <jats:italic>P<\/jats:italic>\u2010values are &lt;0.001, 0.006 and &lt;0.001, respectively). Multivariate survival analysis showed that CC 0\/1, HIPEC, PCI\u2009&lt;\u200920 and low\u2010grade pathological subtype were the independent prognostic factors for better OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PSC does not increase the risk of major perioperative complications in patients with appendiceal PMP, but it also does not bring postoperative survival benefits to patients either.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18041","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T16:20:50Z","timestamp":1663863650000},"page":"219-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Preoperative systemic chemotherapy does not benefit for appendiceal pseudomyxoma peritonei"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-2800","authenticated-orcid":false,"given":"Ruiqing","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Myxoma Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Health Management Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Xue","sequence":"additional","affiliation":[{"name":"Aerospace School of Clinical Medicine Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Myxoma Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichao","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Myxoma Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Myxoma Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Myxoma Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Myxoma Aerospace Center Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199402000-00001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199512000-00006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.04.002"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2010.01.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2012-200843"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000535"},{"key":"e_1_2_8_8_1","first-page":"281","article-title":"Report on the 9th international congress on peritoneal surface malignancies","volume":"11","author":"Li Y","year":"2014","journal-title":"Cancer Biol. 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