{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:27:49Z","timestamp":1791232069303,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bowel ischaemia significantly increases morbidity and mortality from adhesional small bowel obstruction. Current biomarkers and clinical parameters have poor predictive value for ischaemia. Our study investigated whether neutrophil\u2010lymphocyte ratio (NLR) and platelet\u2010lymphocyte ratio (PLR) could be used to predict bowel ischaemia in adhesional small bowel obstruction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This single\u2010centre retrospective study collected clinical, biochemical and radiological data from patients with adhesional small bowel obstruction between 2017 and 2020 who underwent operative management. The presence or absence of bowel ischaemia\/infarction was used to distinguish two populations. Biochemical markers on admission and immediately prior to operation were collected to give platelet\u2010lymphocyte ratio (PLR\n                      <jats:sub>0<\/jats:sub>\n                      and PLR\n                      <jats:sub>PRE\u2010OP<\/jats:sub>\n                      , respectively) and neutrophil\u2010lymphocyte ratio (NLR\n                      <jats:sub>0<\/jats:sub>\n                      and NLR\n                      <jats:sub>PRE\u2010OP<\/jats:sub>\n                      , respectively). SAS 9.4 (SAS Institute Inc., Cary, NC) software was used for data analysis with Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      testing for continuous variables and Pearson Chi\u2010square test for categorical variables. Sensitivity and specificity for PLR and NLR were calculated by means of receiver operating characteristic (ROC) curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010seven patients had intra\u2010operative bowel ischaemia whilst the remaining 73 had no evidence of bowel ischaemia. Both median PLR\n                      <jats:sub>PRE\u2010OP<\/jats:sub>\n                      and NLR\n                      <jats:sub>PRE\u2010OP<\/jats:sub>\n                      were significantly higher in patients with bowel ischaemia compared to those without (PLR\n                      <jats:sub>PRE\u2010OP<\/jats:sub>\n                      272 [IQR 224\u2013433] and 231 [IQR 146\u2013295] respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.027; NLR\n                      <jats:sub>PRE\u2010OP<\/jats:sub>\n                      12.5 [IQR 8.6\u201321.3] v. 5.5 [IQR 3.5\u201310.2] respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.001). Area under the receiver operator characteristic curve (AUC) was 0.762 for NLR\n                      <jats:sub>PRE\u2010OP<\/jats:sub>\n                      , with a sensitivity of 85.1% and specificity of 63% for NLR 7.4.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Raised NLR is predictive of bowel ischaemia in patients with adhesional small bowel obstruction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.18073","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T10:10:23Z","timestamp":1664964623000},"page":"2915-2920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Neutrophil\u2010lymphocyte ratio and platelet\u2010lymphocyte ratio use in detecting bowel ischaemia in adhesional small bowel obstruction"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-788X","authenticated-orcid":false,"given":"Evangeline Phoebe","family":"Woodford","sequence":"first","affiliation":[{"name":"Acute Surgical Unit Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah Mercy","family":"Woodford","sequence":"additional","affiliation":[{"name":"Department of Radiology John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-5979","authenticated-orcid":false,"given":"Amy Rose","family":"Hort","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Westmead Hospital  Sydney New South Wales Australia"},{"name":"Western Clinical School, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1327-9189","authenticated-orcid":false,"given":"Tony Chun","family":"Pang","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Westmead Hospital  Sydney New South Wales Australia"},{"name":"Western Clinical School, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Surgical Innovations Unit Westmead Hospital  Sydney New South Wales Australia"},{"name":"South West Sydney Clinical School University of New South Wales  Liverpool New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent Wai To","family":"Lam","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Westmead Hospital  Sydney New South Wales Australia"},{"name":"Macquarie Medical School Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Bahdah","family":"Nahm","sequence":"additional","affiliation":[{"name":"Acute Surgical Unit Westmead Hospital  Sydney New South Wales Australia"},{"name":"Western Clinical School, Faculty of Medicine and Health University of Sydney  Sydney New South Wales Australia"},{"name":"Surgical Innovations Unit Westmead Hospital  Sydney New South Wales 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