{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T16:16:32Z","timestamp":1777911392761,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rheumatic heart disease (RHD) in young people presents a complex management problem. In Australia a significant proportion of those affected are Aboriginal and Torres Strait Islanders. Transcatheter mitral valve\u2010in\u2010valve (TMViV) replacement has emerged as an alternative to redo surgery in high\u2010risk patients with degenerated mitral bioprostheses. The aim of this study is to review outcomes of TMViV replacement in young patients with RHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre, retrospective review of prospectively collected data on patients undergoing TMViV from December 2017 to June 2021. Primary outcome was major adverse cardiovascular events. Secondary outcome was post\u2010operative trans\u2010thoracic echocardiogram (TTE) results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were seven patients with a mean age of 33\u2009years and predominantly female (<jats:italic>n<\/jats:italic>\u00a0=\u00a05). Pre\u2010operative comorbidities included diabetes (29%), chronic obstructive pulmonary disease (43%), left ventricular dysfunction (43%) and current smoking status (80%). Post\u2010operative median length of hospital stay was 4\u2009days with no post\u2010operative renal failure, stroke, return to theatre, valve embolization or in hospital mortality. Post\u2010operative TTE showed either nil or trivial central mitral regurgitation, no paravalvular leak and a median gradient of 5\u2009mmHg (IQR 4.5, 7) across the new bioprosthesis; sustained at median follow\u2010up of 22\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current literature of TMViV replacement is focused on an older population with concurrent comorbidities. This study provides a unique insight into TMViV replacement in a young cohort of patients with complex social and geographical factors which sometimes prohibits the use of a mechanical valve. The prevalence of RHD remains high for Aboriginal and Torres Strait Islanders, planning for future repeat valve operations should be considered from the outset. We consider TMViV as a part of a staged procedural journey for young patients with RHD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18076","type":"journal-article","created":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T12:40:50Z","timestamp":1665060050000},"page":"3298-3303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcatheter mitral valve\u2010in\u2010valve: treatment of rheumatic heart disease in young patients"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-086X","authenticated-orcid":false,"given":"Abbey","family":"Knox","sequence":"first","affiliation":[{"name":"Cardiothoracic Surgery, Division of Surgery and Perioperative Medicine Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayme S.","family":"Bennetts","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery, Division of Surgery and Perioperative Medicine Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Cardiothoracic Surgery, Department of Surgery, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Gimpel","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery, Division of Surgery and Perioperative Medicine Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard F.","family":"Newland","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery, Division of Surgery and Perioperative Medicine Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Cardiothoracic Surgery, Department of Surgery, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Baker","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery, Division of Surgery and Perioperative Medicine Flinders Medical Centre  Adelaide South Australia Australia"},{"name":"Cardiothoracic Surgery, Department of Surgery, College of Medicine and Public Health Flinders University  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majo X.","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Cardiology Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory D.","family":"Rice","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery, Division of Surgery and Perioperative Medicine Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadarajah","family":"Kangaharan","sequence":"additional","affiliation":[{"name":"Cardiology and Division of Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Sinhal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.13767"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019854"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.02.050"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)62137-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.05.198"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.2974"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2016.1207521"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-021-01677-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009579"},{"key":"e_1_2_8_11_1","first-page":"1","article-title":"Rheumatic mitral valve repair or replacement in the valve\u2010in\u2010valve era","volume":"159","author":"Brescia AA","year":"2020","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003498"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.34"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.157"},{"key":"e_1_2_8_15_1","volume-title":"Acute Rheumatic Fever and Rheumatic Heart Disease in Australia \u2010 in Brief","author":"AIHW","year":"2019"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-14-134"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.01.053"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.049"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2019.07.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivz265"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016851"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.18076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.18076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.18076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T01:13:34Z","timestamp":1692494014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.18076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,6]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/ans.18076"],"URL":"https:\/\/doi.org\/10.1111\/ans.18076","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,6]]},"assertion":[{"value":"2022-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}