{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:39:41Z","timestamp":1747183181640,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aims to assess the effect of primary tumour resection (PTR) on patients with metastatic colorectal cancer (mCRC) treated with cetuximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was conducted in a tertiary cancer center in Turkey. Patients with mCRC between January 2009 and December 2020 were extracted from the electronic hospital management system. Patients with RAS wild\u2010type synchronous metastatic left\u2010sided colon or rectum cancer who had cetuximab\u2010containing treatment protocol were included in the study. The primary outcomes were overall survival (OS) and progression\u2010free survival (PFS). The secondary outcome was response rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 111 patients with mCRC were included in this study. PTR was performed in 57.7% of all patients. Fifty\u2010nine (53.2%) and 52 (46.8%) patients had rectal and left colon tumours, respectively. The combination treatment with cetuximab was FOLFIRI in 62.2% and FOLFOX in 29.7% of all patients. In subgroup analysis, the median PFS was 7.9 and 9\u00a0months in PTR (+) and PTR (\u2212) patients, respectively. The difference between the groups was not statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u20090.3). The median OS was 33\u2009months in all patients. In subgroup analysis, the median OS was 39 and 27.9\u00a0months in PTR (+) and PTR (\u2212) patients, respectively. The difference between the groups was statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u20090.002). After adjusting for confounding factors, PTR and ECOG performance score were the independent prognostic factors for OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PTR improved the OS in patients with RAS wild\u2010type synchronous left\u2010sided colon or rectum cancer treated with cetuximab\u2010containing chemotherapy regimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18117","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T07:11:45Z","timestamp":1666163505000},"page":"945-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of primary tumour resection on patients with synchronous metastatic colorectal cancer treated with cetuximab\u2010containing regimens"],"prefix":"10.1111","volume":"93","author":[{"given":"Elif","family":"Sertesen","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Internal Medicine Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-5930","authenticated-orcid":false,"given":"Emre","family":"Yeked\u00fcz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Oncology Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Berna","family":"K\u00f6ksoy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Oncology Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y\u00fcksel","family":"\u00dcr\u00fcn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Oncology Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayhan B\u00fclent","family":"Erkek","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of General Surgery Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salim","family":"Demirci","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Surgical Oncology Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Ekrem","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Surgical Oncology Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcng\u00f6r","family":"Utkan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Medical Oncology Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization.Estimated age\u2010standardized incidence rates (World) in 2020 worldwide both sexes all ages. 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