{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:12:16Z","timestamp":1769573536808,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100020670","name":"Cancer Council Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013806","name":"Wounds Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012505","name":"Royal Perth Hospital Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000961","name":"State Health Research Advisory Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000961","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Radio\u2010guided occult lesion localisation using iodine 125 seeds (ROLLIS) is used to localize impalpable breast cancers for breast conserving surgery (BCS). Previous studies have suggested improved efficiency and patient outcomes with ROLLIS compared with hook\u2010wire localisation (HWL). The aim of this report is to compare the post\u2010operative complication rates and safety profiles of ROLLIS versus hook\u2010wire guided surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between September 2013 and March 2018, 690 women with non\u2010palpable breast cancer eligible for breast\u2010conserving surgery were randomly assigned to either pre\u2010operative localisation with 125 I seed or hook\u2010wire as part of the ROLLIS clinical trial. Medical record review of 170 women (30% of the total participants) from three tertiary hospitals in Western Australia was performed. Post\u2010operative complications were classified using the Common Terminology Criteria for Adverse Events(CTCAE) grade I to V.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total of 170 surgeries were performed: 82 by ROLLIS and 88 by hook\u2010wire. The overall complication rate in the ROLLIS group was 19.5%, with 15.9% being grade II and 3.66% grade III. In the HWL group, the complication rate was 22.7% with 20.5% being grade II and 2.27% grade III. There was no statistically significant difference in complication grades between the 2 groups. No grade IV or grade V complications were reported. Complications observed included drainable seroma, drainable haematoma and surgical site infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ROLLIS is a safe method of localisation for surgical resection with similar complication rates as hookwires. We encourage its use as an alternative localisation technique as it has demonstrable superiority and efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18329","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T03:54:32Z","timestamp":1676606072000},"page":"876-880","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Iodine\u2010125 seed versus hook\u2010wire guided breast conserving surgery: do post operative complication rates differ?"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-0012","authenticated-orcid":false,"given":"Wei Ling","family":"Ooi","sequence":"first","affiliation":[{"name":"Breast Surgery Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenno","family":"Becker","sequence":"additional","affiliation":[{"name":"General Surgery Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Phillips","sequence":"additional","affiliation":[{"name":"Harry Perkins Institute for Medical Research University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christobel","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1481-1141","authenticated-orcid":false,"given":"Donna","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Royal Perth Hospital  Perth Western Australia Australia"},{"name":"School of Surgery University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"BreastScreen Australia Monitoring Report 2020. Cancer Series no. 129. Cat. no. CAN 135","author":"Australian Institute of Health and Welfare","year":"2020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-019-0803-x"},{"key":"e_1_2_9_4_1","first-page":"88","volume-title":"Management of the Patient with Cancer","author":"Dodd GD","year":"1965"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.12743"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00376-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znaa008"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znaa008"},{"key":"e_1_2_9_9_1","article-title":"Localization techniques for guided surgical excision of non\u2010palpable breast lesions","volume":"31","author":"Chan BK","year":"2015","journal-title":"Cochrane Database Syst. 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