{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:50:41Z","timestamp":1792612241192,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T00:00:00Z","timestamp":1682294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In medically refractory Ulcerative Colitis (UC), proctocolectomy with ileoanal pouch procedure (IAPP) is the preferred continence\u2010preserving surgical option. Functional outcomes post\u2010surgery and long\u2010term complication rates in the biologic era remain ambiguous. This review primarily aims to provide an update on these outcomes. Secondarily, risk factors associated with chronic pouchitis and pouch failure are explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two online databases (MEDLINE and EMBASE) were searched on 4 October 2022 for English studies from 2011\u2010present relating to long\u2010term outcomes of IAPP in inflammatory bowel disease (IBD) patients. Adult patients with 12\u2009month follow\u2010up were included. Studies focused on 30\u2010day post\u2010operative outcomes, non\u2010IBD patients or studies including less than 30 patients were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following screening and full\u2010text review of 1094 studies, 49 were included. Median sample size was\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009282 (IQR: 116\u2013519). Median incidences for chronic pouchitis and pouch failure were 17.1% (IQR: 12\u201323.6%) and 6.9% (IQR: 4.8\u201310.8%), respectively. Upon multivariate analysis, chronic pouchitis development was most significantly associated with pre\u2010operative steroid use, pancolitis and extra\u2010intestinal IBD manifestations, whilst pouch failure was most significantly associated with pre\u2010operative diagnosis of Crohn's disease (compared to UC), peri\u2010operative pelvic sepsis and anastomotic leak. Overall patient satisfaction was very high with four included studies reporting greater than 90% satisfaction rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Long\u2010term complications for IAPP were common. However, despite this, patient satisfaction post\u2010IAPP was high. Up\u2010to\u2010date knowledge of complication rates and their risk factors improves pre\u2010operative counselling, management planning and patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.18490","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T23:11:37Z","timestamp":1682377897000},"page":"1503-1509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Review of long\u2010term complications and functional outcomes of ileoanal pouch procedures in patients with inflammatory bowel disease"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-8225","authenticated-orcid":false,"given":"Yusuf","family":"Hassan","sequence":"first","affiliation":[{"name":"Melbourne Medical School University of Melbourne  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Connell","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St Vincent's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisha","family":"Rawal","sequence":"additional","affiliation":[{"name":"General HMO Stream Grampians Health  Ballarat Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily K.","family":"Wright","sequence":"additional","affiliation":[{"name":"Melbourne Medical School University of Melbourne  Melbourne Australia"},{"name":"Department of Gastroenterology St Vincent's Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252458"},{"key":"e_1_2_8_3_1","first-page":"781","article-title":"Results at up to 20\u2009years after ileal pouch\u2010anal anastomosis for chronic ulcerative colitis","volume":"23","author":"Hahnloser D","year":"2007","journal-title":"Inflamm. 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