{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:18:14Z","timestamp":1774927094281,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Peritoneal malignancies are challenging cancers to manage. While cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS and HIPEC), may offer a cure, it is a radical procedure associated with significant morbidity. Pre\u2010emptive identification of deconditioned patients for optimization may mitigate surgical risk. However, the difficulty lies in identifying a cost\u2010effective predictive tool. Recently, there has been interest in sarcopenia, which may occur due to malignancy. The purpose of this study was to assess the utility of sarcopenia at predicting post\u2010operative outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A quaternary\u2010centre retrospective study of CRS and HIPEC patients (2017\u20132020), were conducted to determine the association between pre\u2010operative sarcopenia on oncological (peritoneal carcinomatosis index (PCI)) and surgical outcomes (complications). Sarcopenia from lumbar CT\u2010images were measured using Slice\u2010o\u2010matic\u2122. Statistical differences were analysed using Mann\u2013Whitney <jats:italic>U<\/jats:italic> and Chi\u2010squared test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Cohort analysis (<jats:italic>n<\/jats:italic>\u2009=\u200994) found 40% had sarcopenia, majority were female (53.2%), and average age of 55\u2009years. The major pathologies was colorectal cancer (<jats:italic>n<\/jats:italic>\u2009=\u200939, 41.5%), appendix adenocarcinoma (<jats:italic>n<\/jats:italic>\u2009=\u200921, 22.3%), and pseudomyxoma peritonei (PMP) (<jats:italic>n<\/jats:italic>\u2009=\u200919, 20.2%). Sarcopenia was associated with decreased weight, 72.7 versus 82.2\u2009kg (<jats:italic>P<\/jats:italic>\u2009=\u20090.014) and shorter survival, 1.4 versus 2.1\u2009years (95% CI, 1.09\u20133.05, <jats:italic>P<\/jats:italic>\u2009=\u20090.032). Median PCI (excluding PMP) was 11 (6\u201318) and median PCI (only PMP) was 25 (11\u201332). Post\u2010operatively, sarcopenia patients experienced more complications (72.5% <jats:italic>vs.<\/jats:italic> 64.8%, <jats:italic>P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pre\u2010emptive identification of sarcopenia may be a useful prognostic indicator and predictor of post\u2010operative outcomes in CRS and HIPEC. For oncological patients, sarcopenia may be an indicator of patients requiring targeted pre\u2010operative rehabilitation, or advanced disease requiring further treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18645","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T04:11:37Z","timestamp":1690863097000},"page":"2186-2191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is the measurement of sarcopenia associated with oncological disease in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy?"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-9805","authenticated-orcid":false,"given":"Adrian Hang Yue","family":"Siu","sequence":"first","affiliation":[{"name":"Surgical Outcomes Research Centre (SOuRCe) Royal Prince Alfred Hospital  Camperdown New South Wales Australia"},{"name":"Faculty of Medicine and Health, Central Clinical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Holyland","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre (SOuRCe) Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Carey","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre (SOuRCe) Royal Prince Alfred Hospital  Camperdown New South Wales Australia"},{"name":"Faculty of Medicine and Health, Central Clinical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9715-860X","authenticated-orcid":false,"given":"Daniel","family":"Steffens","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre (SOuRCe) Royal Prince Alfred Hospital  Camperdown New South Wales Australia"},{"name":"Faculty of Medicine and Health, Central Clinical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabila","family":"Ansari","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre (SOuRCe) Royal Prince Alfred Hospital  Camperdown New South Wales Australia"},{"name":"Faculty of Medicine and Health, Central Clinical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"RPA Institute of Academic Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2547-0204","authenticated-orcid":false,"given":"Cherry E.","family":"Koh","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Research Centre (SOuRCe) Royal Prince Alfred Hospital  Camperdown New South Wales Australia"},{"name":"Faculty of Medicine and Health, Central Clinical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"RPA Institute of Academic Surgery Royal Prince Alfred Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"99","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a review of factors contributing to morbidity and mortality","volume":"7","author":"Newton AD","year":"2016","journal-title":"J Gastrointest Oncol."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.6847"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-016-0504-6"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.06.1312"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12234"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2021.638857"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0204-9"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_543_18"},{"key":"e_1_2_9_10_1","first-page":"2","article-title":"Is preoperative sarcopenia a good predictor of postoperative complications and outcomes after pelvic exenteration surgery?","volume":"3","author":"Hogan S","year":"2020","journal-title":"J. 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