{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:28:35Z","timestamp":1790162915565,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Quality of life (QOL) is an outcome that matters to patients with chronic limb\u2010threatening ischemia (CLTI). However, we identified the lack of and need for a CLTI\u2010specific QOL instrument. Our group is developing this instrument which requires a deep understanding of patient perspectives of QOL in CLTI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Qualitative inquiry with patient and public involvement was performed in accordance with the Standards for Reporting Qualitative Research. Reflexive thematic analysis of semi\u2010structured interviews was conducted within a constructivist\u2010interpretivist research paradigm. Data were organized and managed in NVivo. Techniques to enhance trustworthiness included maintaining an audit trail, member checking, mentoring, and peer\u2010debriefing. Patient and the public were consulted for feedback on codes, themes, and thematic maps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen participants (median age: 74\u2009years, range: 43\u201390\u2009years) with a variety of patient demographics were interviewed. Four themes were developed on QOL in CLTI: (i) \u2018independence as key to life satisfaction\u2019, (ii) \u2018change in identity when continuity is needed\u2019, (iii) \u2018coping with intractable disease\u2019, and (iv) \u2018not wanting to be alone\u2019. Member checking with patient and public involvement confirmed the relevance and centrality of these themes to the lived experiences of patients with CLTI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The thematic outputs contribute important insights into what QOL truly means to patients with CLTI and what matters for their QOL. The content validity of the new CLTI\u2010specific QOL instrument is improved by giving patients voice. This study highlights the value of qualitative inquiry and patient and public involvement in vascular surgical research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18791","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T03:31:20Z","timestamp":1701142280000},"page":"429-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient perspectives of quality of life in chronic limb\u2010threatening ischemia: a qualitative study"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2162-2565","authenticated-orcid":false,"given":"Leonard L.","family":"Shan","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria 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H.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer, Faculty of Medicine Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Choong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Dentistry and Health Sciences The University of Melbourne  Melbourne Victoria 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