{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T01:55:59Z","timestamp":1768528559826,"version":"3.49.0"},"reference-count":42,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>To compare factor(s) contributing to aetiology, management and clinical outcome(s) of paediatric patients acquiring acute pancreatitis (AP) at two major university paediatric surgical centres in Liverpool and Bangkok.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients (&lt;18\u2009years) with an index diagnosis of AP (ICD 10 coding) during 2006\u20132016 were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>121 patients included <jats:italic>n<\/jats:italic>\u2009=\u200979 (65.3%) in Thailand versus <jats:italic>n<\/jats:italic>\u2009=\u200942 (34.7%) in the UK centre with no difference(s) in age at diagnosis at 10.4\u2009\u00b1\u20094.5 and 11.7\u2009\u00b1\u20096\u2009years. (<jats:italic>P<\/jats:italic>\u2009=\u20090.12). Major AP aetiology(s) in Thailand were medications (39.2%) and choledochal cysts (8.9%). In the UK\u2014gallstone disease (21.4%), and medications (16.7%) were leading factors (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Ultrasonography was deployed more frequently in the UK versus Thai centre (74.3% vs. 49.1%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Pancreatitis was confirmed by imaging in 67.9% (Thai) and 62.9% (UK) patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.47). Most patients at both centres had a mild\u2010grade pancreatitis illness (95% Thai vs. 90.5% UK; <jats:italic>P<\/jats:italic>\u2009=\u20090.28) while 12.7% of Thai and 19% of UK children developed pancreatitis\u2010related complication (<jats:italic>P<\/jats:italic>\u2009=\u20090.37). Overall mortality rate (%) was significantly higher in the Thai versus UK centre (27.8% vs. 9.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Aetiology of acute pancreatitis appears to vary between UK and Thailand children. Timely early diagnosis and healthcare pathways may be driven by local patient\u2010related factor(s). The higher mortality (%) observed in Thailand versus UK in this comparative study was linked to underlying co\u2010existent chronic medical condition(s) in vulnerable patient cohorts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18840","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T05:56:42Z","timestamp":1703051802000},"page":"215-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute pancreatitis in childhood \u2013 a comparative international study and tale of two cities"],"prefix":"10.1111","volume":"94","author":[{"given":"Adeline","family":"Salim","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery Alder Hey Children's Hospital NHS Foundation Trust  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-0705","authenticated-orcid":false,"given":"Ampaipan","family":"Boonthai","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pornthep","family":"Tanpowpong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Paediatrics, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Losty","sequence":"additional","affiliation":[{"name":"Division of Paediatric Surgery, Department of Surgery, Faculty of Medicine, Ramathibodi Hospital Mahidol University  Bangkok Thailand"},{"name":"Institute of Systems Molecular and Integrative Biology University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.13"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i4.427"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12873-019-0281-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1994.tb11250.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v5.i4.416"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-1198"},{"key":"e_1_2_8_8_1","first-page":"530","article-title":"Etiology of acute pancreatitis","volume":"9","author":"Ratia T","year":"2014","journal-title":"Cent. 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