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An update on novel therapies used to induce remission in IBD\u2010associated colitis is presented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search through Ovid MEDLINE and CENTRAL using a combination of MeSH terms and Boolean operators was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One thousand and twenty articles from which 38 articles were selected for inclusion in this review. Novel agents were trialled as 4th or 5th line treatment following conventional treatment failure. Rates of serious adverse effects were low. Janus kinase (JAK) inhibitors (upadacitinib and tofacitinib) were efficacious in inducing remission in ulcerative colitis, and IL\u201023p19 inhibitors (mirikizumab, guselkumab, and risankizumab) in Crohn's colitis. Evidence was limited for other drug classes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>JAK\u2010inhibitors and IL\u201023p19 inhibitors were found to be the most effective agents for inducting remission following failure of standard of care treatment. A significant proportion of patients did not respond, highlighting the inherent challenge in optimizing treatment for moderate to severe IBD\u2010associated colitis. More robust study designs and comparator trials are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18924","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:51:33Z","timestamp":1709808693000},"page":"795-803","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Update for surgeons on novel induction treatments for acute severe inflammatory bowel disease associated colitis"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1047-141X","authenticated-orcid":false,"given":"Timothy","family":"Levar","sequence":"first","affiliation":[{"name":"Department of General Surgery (Colorectal) St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medical Education The University of Melbourne, St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Medical Education The University of Melbourne, St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medicine St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nik S.","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Medical Education The University of Melbourne, St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medicine St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-2480","authenticated-orcid":false,"given":"Corina","family":"Behrenbruch","sequence":"additional","affiliation":[{"name":"Department of General Surgery (Colorectal) St Vincent's Hospital Melbourne  Melbourne Victoria Australia"},{"name":"Department of Medical Education The University of Melbourne, St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31711-1"},{"key":"e_1_2_8_4_1","article-title":"Adalimumab for induction of remission in Crohn's disease","volume":"11","author":"Abbass M","year":"2019","journal-title":"Cochrane Database Syst. 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