{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:21:16Z","timestamp":1784679676406,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Superparamagnetic iron oxide (SPIO) (Magtrace\u00ae) is a non\u2010radioactive liquid tracer that can stay in the sentinel lymph nodes for 30\u2009days. Injection of SPIO at time of primary breast surgery where upfront sentinel lymph node biopsy (SLNB) is not immediately indicated allows for a return to theatre if pathology then identifies invasive disease. SLNB is associated with paraesthesia, pain, seroma formation and lymphoedema risk. Hence, our study aims to assess the use of SPIO to avoid upfront SLNB in breast surgery for ductal carcinoma <jats:italic>in situ<\/jats:italic> (DCIS) and prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective single\u2010centre study of consecutive patients who underwent injection of SPIO tracer at time of primary breast surgery to avoid upfront SLNB at Chris O'Brien Lifehouse, Sydney, NSW, Australia over a 10\u2010month period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SPIO was injected 38 times, with 34 at time of mastectomy and four cases at time of wide local excision. The indication for surgery was DCIS in 18 cases, risk reduction in 17 cases and other indications in three patients. Six cases (15.8%) required delayed SLNB (D\u2010SLNB) due to the finding of invasive disease on post\u2010operative histopathology. All patients who underwent D\u2010SLNB had nodes successfully localized with SPIO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort, 84.2% of cases were able to avoid upfront SLNB, and hence avoid the associated complications of SLNB. SPIO injection was successful in localizing the SLN in all cases at time of surgery for D\u2010SLNB. This technique was safe with few associated complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.18936","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T10:41:38Z","timestamp":1709894498000},"page":"1090-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Avoiding unnecessary sentinel lymph node biopsy with the use of superparamagnetic iron oxide mapping agents (Magtrace\u00ae) in breast surgery"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6716-0760","authenticated-orcid":false,"given":"Rebecca Bei Jia","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3644-2747","authenticated-orcid":false,"given":"Susan","family":"Hawes","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Azimi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Mak","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jue Li","family":"Seah","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Warrier","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Chris O'Brien Lifehouse  Camperdown New South Wales Australia"},{"name":"Department of Surgery The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09280-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-07577-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.10.064"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.3759"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/BD-210043"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2023.08.006"},{"key":"e_1_2_7_8_1","unstructured":"Breast Cancer. 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In:guideline N(ed).United Kingdom:2023."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5688-z"},{"key":"e_1_2_7_11_1","unstructured":"Magtrace 330 Cambridge Science Park Milton Road Cambridge CB4 0WN UK.VAT Registration No: GB 947 7709 68: Endomagnetics Ltd (Endomag)2023[Available from:https:\/\/www.endomag.com\/en\/products\/magtrace\/."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-13064-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.01.024"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.06.018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13040693"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.21614\/chirurgia.2673"},{"key":"e_1_2_7_17_1","unstructured":"Magtrace Lymphatic tracer Cincinnati OH 45241: Mammotiome \u00a9 2023 Devicor Medical Products Inc. Available from URL:https:\/\/www.mammotome.com\/us\/en\/products\/magtrace."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2010.10.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004061"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-021-00257-7"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573405618666220415130131"},{"key":"e_1_2_7_22_1","first-page":"1","article-title":"Assessing the Sentimag system for guiding sentinel node biopsies in patients with breast cancer","volume":"1","author":"Abidi H","year":"2023","journal-title":"Expert Rev. Med. Devices"},{"key":"e_1_2_7_23_1","first-page":"122","article-title":"Magnetic marker localisation in breast cancer surgery","volume":"19","author":"Zatecky J","year":"2023","journal-title":"Arch. Med. 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