{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:31:47Z","timestamp":1773048707598,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hashimoto's thyroiditis (HT) is managed with thyroid hormone replacement to maintain a euthyroid state. A subset of patients have refractory symptoms, which improve with thyroidectomy (TT). There remains a reluctance to proceed with surgery due to perceptions of complications, and limited data availability regarding improvements in quality of life (QoL). This retrospective case control study aims to analyse the outcomes and QoL scores for symptomatic euthyroid HT patients who underwent TT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty euthyroid patients who underwent TT for the management of HT between 2017 and 2022 were identified. An age\u2010matched control group of patients who underwent TT for symptomatic multinodular goitre (MNG) were randomly selected. Demographics, biochemistry, histology, outcomes, and pre\u2010 and post\u2010operative SF\u201036 and ThyPRO\u201039 scores were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no surgical complications in the HT group, whilst two MNG patients had complications. There was a similar rate of parathyroid auto\u2010transplantation in both groups, more glands were transplanted in the HT group. There was a significant difference in pre\u2010 and post\u2010operative QoL scores for both groups. Comparison revealed a significant improvement in hyperthyroid symptoms, social life and daily life scores in the HT group. There was a significant difference in pre\u2010 and post\u2010operative anti\u2010TPO, anti\u2010TG and TSH levels in the HT group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with symptomatic Hashimoto's thyroiditis, despite being euthyroid, may benefit from total thyroidectomy however this remains under\u2010utilized. This study demonstrated that thyroidectomy was associated with an improvement in validated post\u2010operative quality of life scores and was not associated with increased complication rates for appropriately selected patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19155","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T11:50:20Z","timestamp":1721130620000},"page":"1800-1805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of thyroidectomy in symptomatic, euthyroid Hashimoto's patients: a case control study"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4602-3337","authenticated-orcid":false,"given":"Hazel","family":"Serrao\u2010Brown","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Royal North Shore Hospital  Sydney New South Wales 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