{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:39:13Z","timestamp":1764571153238,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this study, we investigated the clinical outcomes of patients who underwent surgery with proven lymph node metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were operated for lung cancer with pN1 or pN2 were examined in the study. The clinicopathological features and survival of the subjects were evaluated according to pN1\u2010pN2 status, presence of neoadjuvant treatment, Positron emission tomography and computed tomography (PET\/CT) avidity on mediastinal lymph nodes and specific lymph node stations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study examines 100 patients operated from January 2016 to December 2021. Number of cases with pN1 and pN2 disease were 45 (45%) and 55 (55%) respectively. Thirty (30%) patients received neoadjuvant treatment. The 5\u2010year overall survival (OS) and disease\u2010free survival (DFS) of the patients were computed as 42.5% and 42.4% correspondingly. The 5\u2010year cancer\u2010related survival was 55.3%. In pN2 cohort, 5\u2010year DFS was 67.9% in the neoadjuvant group and 15.9% in the non\u2010neoadjuvant group (<jats:italic>P<\/jats:italic>\u2009=\u20090.042). In non\u2010neoadjuvant group, 5\u2010year DFS was 19.9% in cases with mediastinal PET\/CT avidity and 56.3% in patients without mediastinal PET\/CT avidity (<jats:italic>P<\/jats:italic>\u2009=\u20090.018). In pN2 disease, the presence of subcarinal or paratracheal lymph node metastasis did not create a significant difference in 5\u2010year OS or DFS, but pulmonary ligament lymph node metastasis was found to be linked with worse survival in both 5\u2010year OS (<jats:italic>P<\/jats:italic>\u2009=\u20090.005) and DFS (<jats:italic>P<\/jats:italic>\u2009=\u20090.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The main elements related with poor prognosis were absence of neoadjuvant treatment and pulmonary ligament lymph node metastasis in pN2 disease, detecting PET\/CT avid mediastinal lymph nodes in non\u2010neoadjuvant group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19177","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T05:54:40Z","timestamp":1724910880000},"page":"1781-1786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["What alters prognosis 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Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nedim","family":"Turan","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Kartal Dr. Lutfi Kirdar City Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Recep","family":"Demirhan","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department Kartal Dr. Lutfi Kirdar City Hospital  Istanbul 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