{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:13:29Z","timestamp":1736486009063,"version":"3.32.0"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Rarely, appendiceal neuroendocrine tumours (NET) are an incidental finding when an appendicectomy is undertaken for suspected appendicitis. The role of further imaging in this setting is poorly defined. Positron emission tomography (PET) using <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE is requested to evaluate post\u2010surgical status, however, there is little evidence to guide how it should be employed. The aims of this project are to: (i) characterize <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE PET findings in patients with incidental appendiceal NETs and (ii) discuss how these data might inform post\u2010surgical imaging with PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 47 PET scans in 30 patients, undertaken from 2009 to 2018. Scintigraphic findings, histopathological characteristics of the initial appendiceal lesion and medical records were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients (<jats:italic>n<\/jats:italic>\u2009=\u200915) had small (&lt;10\u2009mm) appendiceal NETs with low grade (Ki67\u2009&lt;\u20092%) features. Eight patients had tumours between 10 and 20\u2009mm, and seven had tumours &gt;20\u2009mm. Goblet cell features were identified in two patients. Three positive PET scans were reported in one patient with an index tumour measuring 40\u2009mm and Ki67\u2009&lt;\u20092%. The remaining 29 patients had 44 negative scans. Clinical outcome data were available in 27 patients (mean follow\u2010up time 57\u2009months; range 6\u2013123\u2009months). There was no evidence of recurrent neuroendocrine disease at the time of the last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data indicate that in most cases, post\u2010surgical <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE PET is negative in patients with incidentally detected appendiceal NETs. Clinical outcome data suggest that <jats:sup>68<\/jats:sup>Ga\u2010DOTATATE PET should be reserved for patients with large tumours (&gt;20\u2009mm) or those displaying goblet cell features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19216","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T12:30:08Z","timestamp":1724416208000},"page":"2185-2188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative <scp><sup>68<\/sup>Ga<\/scp>\u2010<scp>DOTATATE<\/scp> positron emission tomography has a low yield in incidental appendiceal neuroendocrine tumours"],"prefix":"10.1111","volume":"94","author":[{"given":"Emilie","family":"Pauvert","sequence":"first","affiliation":[{"name":"Sydney Medical School University of Sydney  Sydney Australia"},{"name":"Royal Darwin Hospital  Tiwi Northwest Territories Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-976X","authenticated-orcid":false,"given":"George","family":"Larcos","sequence":"additional","affiliation":[{"name":"Sydney Medical School University of Sydney  Sydney Australia"},{"name":"Department of Nuclear Medicine and Ultrasound Westmead Hospital  Westmead New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"601","article-title":"Neuroendocrine neoplasms of the appendix: a review of the literature","volume":"38","author":"Moris D","year":"2018","journal-title":"Anticancer Res."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13332"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0310"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.4377"},{"key":"e_1_2_8_6_1","first-page":"1121","article-title":"Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973\u20102004, and current diagnosis and therapy","volume":"33","author":"Gustafsson BI","year":"2008","journal-title":"Int. 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