{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:17:30Z","timestamp":1784099850783,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Radiation\u2010induced angiosarcoma (RIAS) of the breast is a rare tumour with high rate of local recurrence. The aim of this study is to evaluate the outcome of radical resections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of all patients who underwent extended surgical resection for RIAS of the breast between 2013 and 2022. Included were patients who underwent radical resection, including complete resection of previously irradiated skin and underlying fascia of pectoralis major. Post\u2010operative and long\u2010term oncological outcomes were than analysed. A systematic review was performed using the MEDLINE database in the last 20\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two (<jats:italic>n<\/jats:italic>\u2009=\u200922) patients met the inclusion criteria. The median length of the specimen was 220\u2009mm (range, 120\u2013377\u2009mm). At a median follow\u2010up of 33.5\u2009months (range, 7.9\u2013102.4), 3 (13.6%) patients had both local and metastatic lung disease and 1 (4%) patient with only lung metastasis. The estimated 3\u2010 and 5\u2010year OS was 81.1% and 57.9%, respectively. The estimated 3\u2010 and 5\u2010year DSS was 91.7% and 65.5%, respectively. The estimated 3\u2010 and 5\u2010year DFS rate were both 75.2%. The systematic review identified 17 studies with a recurrence rate ranging from 33% to 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of RIAS of the breast with an up\u2010front locally extended approach is associated with a low rate of local recurrence compared with the reported literature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19231","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T10:43:56Z","timestamp":1725965036000},"page":"2150-2158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes following extended resection of radiation\u2010induced angiosarcoma of the breast: a sarcoma unit experience and systematic review"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-2946","authenticated-orcid":false,"given":"Eyal","family":"Mor","sequence":"first","affiliation":[{"name":"The Peter 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