{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:39:45Z","timestamp":1747183185268,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"1-2","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical characteristics and management of late\u2010onset chylothorax after lung cancer surgery remained unknown. Here we aimed to provide evidence on the management of late\u2010onset chylothorax by analysis of several cases with the largest sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively collected clinical data of patients who developed late\u2010onset chylothorax after lung cancer surgery and were re\u2010admitted by a single surgeon in our center from 2016 to 2022. The clinical characteristics and management for these patients were analysed. The role of Hem\u2010o\u2010lok clipping after lymphadenectomy in preventing late\u2010onset chylothorax was further explored by comparing the surgical outcomes between treated group and control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>A total of six patients who were re\u2010admitted for late\u2010onset chylothorax after lung cancer surgery were included for analysis. The mean age of them was 60.7\u2009years old. The symptom of late\u2010onset chylothorax was mainly dyspnea and cough and the diagnosis was all made by Sudan III staining between postoperative day 17 to 42. All patients were firstly treated with thoracocentesis and low\u2010fat diet with intravenous nutrition. Four patients were successfully managed with low\u2010fat diet and thoracocentesis, while the other two patients were further managed with pleurodesis with 50% glucose fluid solution. We found a significantly decreased risk of late\u2010onset chylothorax in the treated group with improved procedure of applying Hem\u2010o\u2010lok clipping after lymphadenectomy than in the control group (0% versus 2.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Late\u2010onset chylothorax after lung cancer surgery was a rare and negligible complication, which may usually be managed by non\u2010surgical methods. Hem\u2010o\u2010lok clipping during lymphadenectomy seemed to be an effective method to prevent late\u2010onset chylothorax after lung cancer surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19270","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T07:00:21Z","timestamp":1728716421000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Late\u2010onset chylothorax after lung cancer surgery: clinical characteristics, management, and prevention"],"prefix":"10.1111","volume":"95","author":[{"given":"Jindong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaili","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijuan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-6259","authenticated-orcid":false,"given":"Xiaojun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5963-8103","authenticated-orcid":false,"given":"Han\u2010Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daxing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery West China Hospital, Sichuan University  Chengdu China"},{"name":"Lung Cancer Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12025"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.4932"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezab028"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.04.015"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.03.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015909"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-005-1007-5"},{"key":"e_1_2_12_10_1","first-page":"345","article-title":"Late\u2010period\u2010onset chylothorax after a pulmonary resection for lung cancer: a case report","volume":"13","author":"Suemitsu R","year":"2007","journal-title":"Ann. Thorac. Cardiovasc. Surg."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2009.10.005"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.cr.08.01373"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-010-0635-6"},{"key":"e_1_2_12_14_1","first-page":"1052","article-title":"Late\u2010onset chylothorax after right upper lobectomy;report of a case","volume":"71","author":"Sakaizawa T","year":"2018","journal-title":"Kyobu Geka"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv041"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(03)00020-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.10.065"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.02.13"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.19270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T01:27:03Z","timestamp":1743557223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.19270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":17,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/ans.19270"],"URL":"https:\/\/doi.org\/10.1111\/ans.19270","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"type":"print","value":"1445-1433"},{"type":"electronic","value":"1445-2197"}],"subject":[],"published":{"date-parts":[[2024,10,11]]},"assertion":[{"value":"2024-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}