{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:46:46Z","timestamp":1755798406663,"version":"3.44.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on optimal extent of resection for various stages of gallbladder cancer are lacking. This study aims to evaluate disease\u2010free (DFS) and overall survival (OS) after simple (SC) versus radical cholecystectomy (RC) for gallbladder cancer in the Australian context, and assesses factors associated with post\u2010operative morbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multi\u2010centre, retrospective cohort analysis including all gallbladder cancer patients who underwent resection across six Australian institutions between January 2010 and January 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 63 patients included, 31 underwent SC and 32 had RC. Liver and other organ resection correlated with prolonged median DFS (41.9 <jats:italic>vs.<\/jats:italic> 13.1\u2009months, HR 0.492 [95% CI 0.245\u20130.987], <jats:italic>P<\/jats:italic>\u2009=\u20090.042) and OS on univariate analysis of all patients (55.8% survived five years follow\u2010up at study conclusion <jats:italic>vs.<\/jats:italic> median 18.4\u2009months, HR 0.66 [95% CI 0.446\u20130.972], <jats:italic>P<\/jats:italic>\u2009=\u20090.036) but failed to demonstrate effect on multivariable analysis (OS HR 0.31 [95% CI 0.09\u20131.04], <jats:italic>P<\/jats:italic>\u2009=\u20090.057). RC was associated with a higher 30\u2010day complication rate (<jats:italic>n<\/jats:italic>\u2009=\u200921 [65.6%] <jats:italic>vs. n<\/jats:italic>\u2009=\u200915 [48.4%], <jats:italic>P<\/jats:italic>\u2009=\u20090.310) compared to SC, although not statistically significant. There was no significant difference in the major morbidity rate (Clavien\u2010Dindo\u2009\u2265\u2009Grade III) observed after SC (<jats:italic>n<\/jats:italic>\u2009=\u20097 [22.6%]) compared with RC (<jats:italic>n<\/jats:italic>\u2009=\u20096 [18.7%], <jats:italic>P<\/jats:italic>\u2009=\u20090.754). Neoadjuvant therapy was not utilized and adjuvant treatment used infrequently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extended gallbladder cancer resection was associated with prolonged OS and DFS but also considerable post\u2010operative morbidity. Further studies are warranted to determine the optimal extent of surgical resection by stage of gallbladder cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19300","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T07:58:51Z","timestamp":1733126331000},"page":"395-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Operative management and outcomes of gallbladder cancer in <scp>Australia<\/scp>: a multi\u2010institutional, retrospective, observational cohort analysis"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-7215","authenticated-orcid":false,"given":"Jordan","family":"Santucci","sequence":"first","affiliation":[{"name":"Hepatopancreaticobiliary Unit St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"},{"name":"Department of General Surgery Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Surgical Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathy","family":"Hua","sequence":"additional","affiliation":[{"name":"Hepatopancreaticobiliary Unit St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Chong","sequence":"additional","affiliation":[{"name":"Hepatopancreaticobiliary Unit St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5223-5958","authenticated-orcid":false,"given":"Elizabeth","family":"Lockie","sequence":"additional","affiliation":[{"name":"Department of General Surgery Royal Melbourne Hospital  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of General Surgery Eastern Health  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of General Surgery Monash Health  Clayton Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren","family":"Zhou","sequence":"additional","affiliation":[{"name":"Departent of General Surgery Epworth Eastern Hospital  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"Hepatopancreaticobiliary Unit St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"},{"name":"Department of General Surgery Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Department of Surgical Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Departent of General Surgery Epworth Eastern Hospital  Box Hill Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Melbourne HPB Collaborative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2017.1284895"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2019.85166"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.14701\/ahbps.21\u2010169"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.16663"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2019.06.06"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2022.06.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.521"},{"key":"e_1_2_9_9_1","unstructured":"National Comprehensive Cancer Network.Hepatobiliary Cancers Pennsylvania: National Comprehensive Cancer Network;2022Version 2: Available from:https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=1&id=1438."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2012.00559.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.02.031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-008-0772-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181675842"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3527-7"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.593"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2021.12.019"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.506"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.128"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.705299"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101951"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12444"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0112"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v13.i6.625"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2021.11.131"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31462-9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0276599"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-6025-x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11618"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00398-y"},{"key":"e_1_2_9_31_1","unstructured":"MemisB RoaJC MurakiT.Not all T2 gallbladder carcinomas (GBC) are equal: proposal for sub\u2010staging of T2 GBC with significant prognostic value. (Abstract)."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-0914-4"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1134-3"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0309-6"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1503\/cjs.019719"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-019-08074-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-0189-3"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.19300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T07:24:44Z","timestamp":1755588284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.19300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,2]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/ans.19300"],"URL":"https:\/\/doi.org\/10.1111\/ans.19300","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"type":"print","value":"1445-1433"},{"type":"electronic","value":"1445-2197"}],"subject":[],"published":{"date-parts":[[2024,12,2]]},"assertion":[{"value":"2024-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}