{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:14:47Z","timestamp":1771632887402,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Investigate incidence and identify predictors of axillary lymph node metastases in early breast cancer in women &gt;74\u2009years Australia and New Zealand to inform decision making about sentinel lymph node (SLN) biopsy in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of invasive breast cancer in women in Australia and New Zealand between 2010 and 2022 using BreastSurgANZ Quality Audit Database. Data included patient demographics, tumour characteristics, surgery type, axillary nodal status and adjuvant therapy. Descriptive analysis of incidence of axillary nodal metastases and use of adjuvant therapy in various patient and tumour groups was performed, followed by statistical analysis using multivariate logistic regression to identify predictors of axillary nodal positivity and correlation between nodal status and prescription of adjuvant therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Review of 127\u2009436 cases of invasive breast cancer, 17\u2009599 cases &gt;74\u2009years. Two thirds of the overall population and in those &gt;74\u2009years were node negative. In patients &gt;74\u2009years with grade 1\u20132, T1a\u2010b cancers, ER+\/HER2\u2212 94% were node negative. Patient age, tumour size, grade and biomarker profile correlated with axillary nodal status and analysis of adjuvant therapy revealed significant correlation between nodal stage and adjuvant radiotherapy, chemotherapy and endocrine therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A total of 94% of patients &gt;74\u2009years with T1a\/b, ER positive HER2 negative breast cancer were node negative. Nodal status significantly influences adjuvant treatment in this patient group and therefore, we recommend clinicians consider tumour factors and patient fitness in their decision making about SLN biopsy in the elderly population with hormone receptor positive early breast cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19313","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T12:55:00Z","timestamp":1732712100000},"page":"2159-2164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is routine axillary staging still required in clinically node negative early breast cancer in women over 74\u2009years?"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5883-8701","authenticated-orcid":false,"given":"Katherine","family":"Grant","sequence":"first","affiliation":[{"name":"Department of Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3774-6186","authenticated-orcid":false,"given":"Xiang Yuen","family":"Po","sequence":"additional","affiliation":[{"name":"Department of Surgery Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leong","family":"Tiong","sequence":"additional","affiliation":[{"name":"Department of Breast &amp; Endocrine Surgery Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2014.08.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.1177"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2010.42.1.30"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970515)79:10<1918::AID-CNCR12>3.0.CO;2-Y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.3759"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-015-0404-2"},{"key":"e_1_2_9_8_1","unstructured":"National Cancer Institute.Sentinel Lymph Node Biopsy. 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