{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T16:19:34Z","timestamp":1777133974756,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mass\u2010forming intrahepatic cholangiocarcinoma (MF\u2010ICC) is the second most common primary liver cancer and liver resection offers the best chance of possible cure. This study aimed to assess treatment outcomes and prognostic factors for long\u2010term survival in patients who underwent curative\u2010intent liver resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on prospectively collected data from patients with MF\u2010ICC managed at the Royal North Shore\/North Shore Private Hospital from January 1998 to October 2023. Baseline, peri\u2010operative and long\u2010term outcomes have been analysed, including an overall survival (OS) and disease\u2010free survival (DFS) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 25\u2010year study period, 47 patients underwent curative\u2010intent liver resection for primary MF\u2010ICC at a median age of 70\u2009years. The median OS was 36\u2009months, with a 5\u2010year OS of 33%. Multiple liver tumours (HR\u2009=\u20092.84; 95% CI\u2009=\u20091.24\u20136.48; <jats:italic>P<\/jats:italic>\u2009=\u20090.013) and a positive resection margin (HR\u2009=\u20092.46; 95% CI\u2009=\u20091.10\u20135.52; <jats:italic>P<\/jats:italic>\u2009=\u20090.029) were identified as independent predictors of poor long\u2010term OS. Recurrence occurred in 62% of patients after a median DFS of 16\u2009months, with poor tumour differentiation (HR\u2009=\u20093.93; 95% CI\u2009=\u20091.62\u20139.54; <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and elevated tumour markers (HR\u2009=\u20093.47; 95% CI\u2009=\u20091.53\u20137.87; <jats:italic>P<\/jats:italic>\u2009=\u20090.003) as independent predictors of poor DFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver resection can offer a significant chance for prolonged survival in a highly selected population of patients with MF\u2010ICC. However, the surgical challenges inherent in treating this rare disease are evident, emphasizing the need for a multimodal approach and continued exploration of additional therapies to enhance personalized treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19326","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T10:26:33Z","timestamp":1733480793000},"page":"934-941","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mass\u2010forming intrahepatic cholangiocarcinoma: treatment outcomes after curative\u2010intent resection in an Australian tertiary referral hospital"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8716-2580","authenticated-orcid":false,"given":"Sander R. W. 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