{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:51:44Z","timestamp":1791899504519,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to investigate the causes of failure after the ileal pouch\u2010anal anastomosis (IPAA) procedure for ulcerative colitis (UC) and to determine the independent risk factors affecting their quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multi\u2010center cohort study included all UC patients who underwent IPAA at nine referral centers in T\u00fcrkiye from 2010 to 2018. Centers were categorized as high\u2010volume (\u226510 cases\/year) or low\u2010volume (&lt;10 cases\/year). Outcomes assessed included postoperative complications, pouch failure, and QoL using the Cleveland Global Quality of Life (CGQL) and modified Oresland Score. Logistic and linear regression analyses were used to identify risk factors for pouch failure and QoL determinants, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 296 patients included, pouches were constructed in 172 (58.1%) as a two\u2010staged and in the remaining patients as a three\u2010staged procedure. The high\u2010volume center had higher rates of biologic (45.1% versus 16%) and steroid use (63.9% versus 22.1%). The overall pouch failure rate was 4.7% at the end of follow\u2010up of 66.1\u2009months. Independent risk factors for pouch failure included pelvic sepsis (OR\u2009=\u200947.47, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), biologic use (OR\u2009=\u200913.45, <jats:italic>P<\/jats:italic>\u2009=\u20090.033), chronic pouchitis (OR\u2009=\u200914.31, <jats:italic>P<\/jats:italic>\u2009=\u20090.013), postoperative blood transfusion (OR\u2009=\u20097.04, <jats:italic>P<\/jats:italic>\u2009=\u20090.048), and low annual case volume (OR\u2009=\u200930.86, <jats:italic>P<\/jats:italic>\u2009=\u20090.047). CGQL and Oresland scores averaged 0.77\u2009\u00b1\u20090.1 and 6.3\u2009\u00b1\u20091.1, respectively. Factors negatively impacting QoL included two\u2010staged procedures, small bowel obstruction, venous thromboembolism, chronic pouchitis, increased frequency of bowel movements, and low annual case volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IPAA surgery in UC patients in T\u00fcrkiye demonstrates acceptable rates of complications and pouch failure, with high patient satisfaction in terms of QoL and functional outcomes. Optimizing long\u2010term results requires enhanced surgical expertise and coordinated multidisciplinary management strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19336","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T07:50:11Z","timestamp":1733471411000},"page":"457-463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors of pouch failure and quality of life following ileal pouch\u2010anal anastomosis for ulcerative colitis: a retrospective multicenter study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5993-9536","authenticated-orcid":false,"given":"Ahmet","family":"Rencuzogullari","sequence":"first","affiliation":[{"name":"Department of General Surgery, Division of Colorectal Surgery, School of Medicine Ko\u00e7 University, \u00c7ukurova University  Istanbul Adana 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