{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T07:10:02Z","timestamp":1747293002994,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Submandibular gland pathology is common but rarely reported. This study was performed to evaluate demographic, pathological, and survival outcomes associated with submandibular gland extirpation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of patients treated in a single quaternary\u2010care institution between 1989 and 2022 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and sixty patients underwent submandibular gland extirpation with a female preponderance (<jats:italic>n<\/jats:italic>\u2009=\u2009271, 59%) and a mean age of 51\u2009years. Older age was associated with increased risk of malignancy (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Submandibular calculus was the most common pathology, with gland extirpation for this indication decreasing over time (<jats:italic>P<\/jats:italic>\u2009=\u20090.005). Pleomorphic adenoma was the most common benign tumour (<jats:italic>n<\/jats:italic>\u2009=\u200996, 52.7% of total tumours), and adenoid cystic carcinoma was the most common malignant tumour (<jats:italic>n<\/jats:italic>\u2009=\u200925, 13.7% of total tumours).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Submandibular calculus remains the most common indication for submandibular gland extirpation, although the rate is decreasing over time. Pleomorphic adenoma continues to be the most common tumour of the submandibular gland, whilst adenoid cystic carcinoma is the most common malignant tumour. The incidence of benign versus malignant tumours has remained constant over the period of this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.19358","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T09:54:40Z","timestamp":1735638880000},"page":"713-718","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A review of submandibular gland extirpation in an Australian quaternary referral centre: aetiologies and trends over 35\u2009years"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5316-9924","authenticated-orcid":false,"given":"Aki Constantine","family":"Flame","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Gupta","sequence":"additional","affiliation":[{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital, NSW Health Pathology  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Robert","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"},{"name":"The Royal Prince Alfred Institute of Academic Surgery Sydney Local Health District  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-2114","authenticated-orcid":false,"given":"Michael","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerwin Frank","family":"Shannon","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten Erich","family":"Palme","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Wykes","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica Ka\u2010Yan","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital, NSW Health Pathology  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9171-9878","authenticated-orcid":false,"given":"Timothy","family":"Manzie","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsu\u2010Hui (Hubert)","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Chris O'Brien Lifehouse  Sydney New South Wales Australia"},{"name":"Sydney Medical School, Faculty of Medicine and Health Sciences The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Otolaryngology\u2010Head &amp; 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