{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:52:59Z","timestamp":1773417179442,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is uncertainty when determining the optimal treatment for malignant polyps. Clinicians must balance the oncological risk of a malignant polyp with the risk of morbidity and mortality from surgery. This study developed an online risk\u2010calculator using machine\u2010learning techniques to predict the risk of an adverse outcome from a malignant colorectal polyp following polypectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data collection of a population\u2010wide database of all malignant polyps from 2011 to 2020 was performed. Utilizing an artificial intelligence\u2010based machine learning approach a generalized linear mixed (GLM) model was developed to predict the risk of an adverse outcome after polypectomy. The presence of an adverse outcome was determined by assessing for the presence of residual disease or lymphatic disease if colorectal resection was undertaken. Delayed disease recurrence was also assessed as an additional adverse outcome. Patient and pathological details from the Queensland Cancer Registry were collected and included in the calculator development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The following variables were included in the final model: age, gender, polyp location (right colon, left colon, rectum), depth of tumour invasion, lymphovascular space invasion, tumour grade, associated polyp type, mismatch repair immunohistochemistry status and margin status. Based on ROC analysis, the AUC for the final GLM model was 0.76. The mean accuracy of the GLM model was 0.76 (95% CI: 0.72\u20130.80).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This web\u2010based nomogram will facilitate the discussion of whether individual patients with malignant colorectal polyps can be safely managed with polypectomy or whether the patient should undergo colorectal resection. This nomogram is now available at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/malignantpolyp.com\/risk-calculator\">https:\/\/malignantpolyp.com\/risk-calculator<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.19384","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T02:53:11Z","timestamp":1738205591000},"page":"1190-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Development of a novel malignant colorectal polyp prognostic nomogram"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-220X","authenticated-orcid":false,"given":"Andrew P","family":"Zammit","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yagiz Alp","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"},{"name":"NSW Health Pathology, Department of Anatomical Pathology Royal North Shore Hospital  Sydney New South Wales 2065 Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-2547","authenticated-orcid":false,"given":"Ian","family":"Brown","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"Envoi Specialist Pathologists  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-8486","authenticated-orcid":false,"given":"John D","family":"Hooper","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Mater Research Translational Research Institute  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2065-3012","authenticated-orcid":false,"given":"David A","family":"Clark","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"},{"name":"Faculty of Medicine and Health University of Sydney and Surgical Outcomes Research Centre (SOuRCe)  Sydney New South Wales Australia"},{"name":"St Vincent's Private Hospital Northside  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-6822","authenticated-orcid":false,"given":"Talia L","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 2006 Australia"},{"name":"Douglass Hanly Moir Pathology  Macquarie Park New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8648-0919","authenticated-orcid":false,"given":"Andrew D","family":"Riddell","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Surgery Redcliffe Hospital  Redcliffe Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-1967","authenticated-orcid":false,"given":"Anthony J","family":"Gill","sequence":"additional","affiliation":[{"name":"Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research Royal North Shore Hospital  St Leonards New South Wales 2065 Australia"},{"name":"NSW Health Pathology, Department of Anatomical Pathology Royal North Shore Hospital  Sydney New South Wales 2065 Australia"},{"name":"Sydney Medical School University of Sydney  Sydney New South Wales 2006 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"ZammitAP LyonsN HooperJ BrownI ClarkD RiddellA.Adverse histological features or clinical considerations predicting segmental resection after endoscopic removal of malignant colorectal polyps: a systematic review. 2021. 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