{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:54:48Z","timestamp":1772988888020,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the predictive value of day zero post\u2010operative parathyroid hormone (PTH) levels in determining cure for primary hyperparathyroidism (pHPT) following parathyroidectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre, retrospective diagnostic accuracy study utilized data from a single surgeon. Patients who underwent parathyroidectomy for pHPT were included, with exclusions for secondary or tertiary causes and incomplete follow\u2010up. Day zero post\u2010operative PTH levels were the key predictor variable, while cure at 6\u2009months, defined by normocalcaemia, was the outcome. Diagnostic parameters including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated for an optimal PTH cut\u2010off determined using a receiver operating characteristic (ROC) curve and Youden's index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 291 patients included, 278 (95.5%) were cured at 6\u2009months. An optimal PTH cut\u2010off of &lt;3\u2009pmol\/L was identified, correlating with a true positive rate of 81.3% and a false positive rate of 0%. Patients with day zero PTH &lt;3\u2009pmol\/L (77.7% of the cohort) were all cured at six months. The PTH &lt;3\u2009pmol\/L cut\u2010off demonstrated a sensitivity of 81.3%, specificity of 100%, PPV of 100%, NPV of 20%, and an accuracy of 82.1%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Day zero post\u2010operative PTH level\u2009&lt;\u20093\u2009pmol\/L is a reliable predictor of cure for pHPT following parathyroidectomy. A PTH level of &lt;3\u2009pmol\/L is an effective cut\u2010off to identify patients who will be cured, potentially reducing the need for prolonged biochemical monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.19411","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T02:52:31Z","timestamp":1738205551000},"page":"1842-1846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Day zero parathyroid hormone levels predict cure after parathyroidectomy"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3878-6163","authenticated-orcid":false,"given":"Brodie D","family":"Laurie","sequence":"first","affiliation":[{"name":"Endocrine Surgery Sir Charles Gairdner Hospital  11\/13 Bridge Street Wilson Western Australia 6107 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4552-9579","authenticated-orcid":false,"given":"David","family":"Leong","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Sir Charles Gairdner Hospital  11\/13 Bridge Street Wilson Western Australia 6107 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hieu","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Sir Charles Gairdner Hospital  11\/13 Bridge Street Wilson Western Australia 6107 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Ryan","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Sir Charles Gairdner Hospital  11\/13 Bridge Street Wilson Western Australia 6107 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Lisewski","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Fiona Stanley Hospital  Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Primary Hyperparathyroidism","author":"Pokhrel B","year":"2023"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_9_4_1","article-title":"Parathyroidectomy for adults with primary hyperparathyroidism","volume":"2023","author":"Pappachan JM","year":"2023","journal-title":"Cochrane Database Syst. 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