{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T08:53:01Z","timestamp":1775206381897,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The introduction of non\u2010vitamin\u2010K\u2010antagonist oral anticoagulants (NOAC) has shifted the landscape of anticoagulation in the setting of atrial fibrillation (AF), as an alternative to warfarin. Despite extensive evidence for NOACs in non\u2010perioperative and non\u2010valvular AF, there remains little consensus on anticoagulation choice for patients with postoperative atrial fibrillation (POAF) after cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective, observational study included 2263 patients who underwent cardiac surgery between 1 March 2016 and 13 January 2023 at a tertiary cardiac centre. Patients with pre\u2010existing AF, valvular AF and transcatheter interventions were excluded. Short\u2010 and long\u2010term outcomes were compared between patients who received a NOAC and those who received warfarin for POAF. A Cox regression model was constructed to identify independent predictors for time\u2010to\u2010mortality. Subgroup analysis was performed based on the type of surgery, including CABG\u2010only, aortic valve replacement (AVR)\u2010only, and combined surgery cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 2263 patients, 556 (24.5%) developed POAF. Of those who developed POAF, 162 were anticoagulated with warfarin and 65 were anticoagulated with a NOAC, including apixaban, rivaroxaban and dabigatran. There were three cases of permanent stroke in the warfarin group compared with no cases in the NOAC group. All\u2010cause 30\u2010day and one\u2010year readmission rates were similar between groups. The use of NOAC or warfarin did not impact overall survival in the Kaplan\u2013Meier analysis. Subgroup analysis demonstrated similar outcomes in CABG\u2010only, AVR\u2010only and combined surgery groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Warfarin and NOAC performed similarly in short\u2010 and long\u2010term complications, suggesting NOAC as a plausible alternative to warfarin for anticoagulation in POAF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70045","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T06:53:10Z","timestamp":1741589590000},"page":"1135-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early use of non\u2010vitamin K antagonist oral anticoagulants after cardiac surgery compared with warfarin for postoperative atrial fibrillation"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6492-3742","authenticated-orcid":false,"given":"Shantel","family":"Chang","sequence":"first","affiliation":[{"name":"Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine and Dentistry Griffith University  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4009-117X","authenticated-orcid":false,"given":"Alexander","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Smith","sequence":"additional","affiliation":[{"name":"St Andrews War Memorial Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Lawler","sequence":"additional","affiliation":[{"name":"Princess Alexandra Hospital  Brisbane Queensland Australia"},{"name":"School of Medicine and Dentistry Griffith University  Gold Coast Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry Griffith University  Gold Coast Queensland Australia"},{"name":"Gold Coast University Hospital  Southport Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrie","family":"Stroebel","sequence":"additional","affiliation":[{"name":"Gold Coast University Hospital  Southport Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15396"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.12.010"},{"key":"e_1_2_10_4_1","first-page":"744","article-title":"Postoperative atrial fibrillation following coronary artery bypass graft surgery predicts long\u2010term atrial fibrillation and stroke","volume":"18","author":"Konstantino Y","year":"2016","journal-title":"Isr. Med. Assoc. J."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023921"},{"key":"e_1_2_10_6_1","first-page":"e1","article-title":"ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar JA","year":"2023","journal-title":"Circulation"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa612"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.09.064"},{"key":"e_1_2_10_9_1","unstructured":"ANZSCTS.ANZSCTS National Cardiac Surgery Database Data Definitions Manual. Available from URL:http:\/\/anzscts.org\/wp-content\/uploads\/2018\/01\/ANZSCTS-Data-Definition-Manual-v4.1.pdf"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.17203"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.12.031"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14054"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2020.04.018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2015.07.005"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013032"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004459"},{"key":"e_1_2_10_17_1","unstructured":"The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial (DANCE).ClinicalTrials.gov identifier: NCT04284839. [Cited 13 Mar 2024.] Available from URL:https:\/\/clinicaltrials.gov\/study\/NCT04284839"}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70045","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70045","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:06:46Z","timestamp":1770196006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,23]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/ans.70045"],"URL":"https:\/\/doi.org\/10.1111\/ans.70045","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,23]]},"assertion":[{"value":"2024-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}