{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:19:20Z","timestamp":1792696760603,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016304","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The current standard for lymph node (LN) sampling in colorectal cancer (CRC) surgery is a minimum of 12 LNs. Emerging evidence suggests higher LN yields may improve disease\u2010free survival (DFS); however, an \u201coptimal\u201d number of LNs has yet to be definitively established. The aim of this study was to correlate LN yield with survival outcomes in patients undergoing surgery for nonmetastatic CRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Bowel Cancer Outcomes Registry (BCOR) is a clinical quality registry in Australia and New Zealand. Post\u2010operative patients aged \u2265\u200918\u2009years with histologically confirmed CRC, nonmetastatic disease at diagnosis and with follow\u2010up status documented were included. Post\u2010operative outcomes and survival were assessed with logistic regression. The primary endpoint was CRC\u2010specific mortality. Secondary endpoints were CRC recurrence and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 91\u2009271 patient episodes, 10\u2009616 individual eligible patients were identified (45.4% male, <jats:italic>n<\/jats:italic>\u2009=\u20094828). The median number of LNs resected was 18 [quartiles 0\u201312, 13\u201317, 18\u201323 and &gt;\u200923]. A significant difference in CRC\u2010specific mortality was seen between quartiles (<jats:italic>p\u2009=<\/jats:italic>\u20090.023), with the primary significant difference demonstrated between the lowest quartile (\u2264\u200912 LNs) and other groups. On long\u2010term follow\u2010up, CRC recurrence and CRC\u2010specific mortality were higher in the group with \u2264\u200912 LNs resected (16.0% vs. 14.0%, adjusted <jats:italic>p\u2009=<\/jats:italic>\u20090.049 and 4.5% vs. 3.3%, adjusted <jats:italic>p\u2009=<\/jats:italic>\u20090.037 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study supports the current consensus that &gt;\u200912 LNs are required for adequate staging and oncological clearance in CRC surgery, and demonstrates yields \u2264\u200912 LNs are associated with higher CRC recurrence and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.70150","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:31:00Z","timestamp":1745397060000},"page":"1509-1516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lymph Node Yield and Colorectal Cancer Survival: A Bowel Cancer Outcomes Registry Cohort Study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7376-5931","authenticated-orcid":false,"given":"Bruce D.","family":"Wilkie","sequence":"first","affiliation":[{"name":"Department of Surgery Eastern Health  Box Hill Victoria Australia"},{"name":"Faculty of Medicine, Dentistry &amp; Health Sciences The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of General Surgery Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-8800","authenticated-orcid":false,"given":"James M.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Surgery Eastern Health  Box Hill Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Paratz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry &amp; Health Sciences The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of Cardiology St Vincent's Hospital Melbourne  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Proud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry &amp; Health Sciences The University of Melbourne  Parkville Victoria Australia"},{"name":"Department of General Surgery Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Smart","sequence":"additional","affiliation":[{"name":"Department of Surgery Eastern Health  Box Hill Victoria Australia"},{"name":"Department of General Surgery Austin Health  Heidelberg Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinna","family":"An","sequence":"additional","affiliation":[{"name":"Department of Surgery Eastern Health  Box Hill Victoria Australia"},{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2019.03.027"},{"issue":"5","key":"e_1_2_9_3_1","first-page":"561","article-title":"Prognostic and Predictive Factors in Colorectal Cancer","volume":"61","author":"Zlobec I.","year":"2008","journal-title":"Journal of Clinical Pathology"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800761118"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000002323"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13708"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.022"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-0979-PFICC"},{"issue":"4","key":"e_1_2_9_9_1","first-page":"1","article-title":"Adjuvant Therapy for Patients With Colon and Rectum Cancer","volume":"8","year":"1990","journal-title":"Consensus Statement"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb00867.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<666::AID-CNCR6>3.0.CO;2-I"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604011"},{"key":"e_1_2_9_14_1","unstructured":"H. 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