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It has been suggested that the appendix is central to nurturing the enteric mucosal system due to its production of lymphoid products and that an appendicectomy may have an immune modulating effect. The aim of this review is to explore the available evidence for the association between IBD and appendicectomy and attempt to define its impact on the incidence and risk of Crohn's disease (CD) and Ulcerative colitis (UC) onset and progression.<\/jats:p>","DOI":"10.1111\/ans.70157","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T10:52:14Z","timestamp":1747306334000},"page":"1091-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Place of Appendicectomy in Inflammatory Bowel Disease\u2014A Review"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-8791","authenticated-orcid":false,"given":"Krishanth","family":"Naidu","sequence":"first","affiliation":[{"name":"Colorectal Surgery Unit Concord Hospital  Concord Australia"},{"name":"Concord Institute of Academic Surgery Concord Hospital  Concord Australia"},{"name":"Concord Clinical School, Clinical Sciences Building, Concord Hospital University of Sydney  Concord Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8167-2831","authenticated-orcid":false,"given":"Pearl","family":"Wong","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit Concord Hospital  Concord Australia"},{"name":"Concord Clinical School, Clinical Sciences Building, Concord Hospital University of Sydney  Concord Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre H.","family":"Chapuis","sequence":"additional","affiliation":[{"name":"Colorectal Surgery Unit Concord Hospital  Concord Australia"},{"name":"Concord Institute of Academic Surgery Concord Hospital  Concord Australia"},{"name":"Concord Clinical School, Clinical Sciences Building, Concord Hospital University of Sydney  Concord Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J. 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