{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:05:04Z","timestamp":1757617504999,"version":"3.44.0"},"reference-count":24,"publisher":"Wiley","issue":"7-8","license":[{"start":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T00:00:00Z","timestamp":1746748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postoperative venous thromboembolism (VTE) prophylaxis for hepatectomy is debated in low\u2010VTE incidence regions like Thailand due to bleeding risks. This study evaluated single\u2010dose preoperative enoxaparin safety for VTE prophylaxis, focusing on post\u2010hepatectomy hemorrhage (PHH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective review compared VTE and PHH incidence before (no prophylaxis) and after implementation of a single preoperative dose of enoxaparin 40\u2009mg for all patients undergoing elective hepatectomy in a center in Thailand. PHH and post\u2010hepatectomy liver failure (PHLF) were defined per International Study Group of Liver Surgery criteria. Factors associated with PHH were analyzed using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred eighty\u2010six patients underwent elective hepatectomy (mean age 58\u2009years). Fifty\u2010two percent underwent major hepatectomy. PHLF occurred in 11% of patients. VTE occurred in 0% (0\/96) of the pre\u2010protocol and 1.1% (1\/90) of the post\u2010protocol group. PHH rate was 3.8%, with no difference between pre\u2010protocol (3\/96) and post\u2010protocol groups (4\/90). Factors associated with PHH were intraoperative transfusion &gt;\u20092 units (OR 33.3; 95% CI 1.9\u2013587.7) and PHLF (OR 17.2; 95% CI 2.1\u2013140.8), but not enoxaparin (OR 1.9; 95% CI 0.3\u201312.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Single preoperative enoxaparin did not increase PHH risk in this low VTE incidence cohort and may be considered for VTE prophylaxis in similar populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ans.70168","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T07:13:48Z","timestamp":1746774828000},"page":"1454-1461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety of Single Preoperative Dose of Enoxaparin for Hepatectomy: A Study in a Country With Low Venous Thromboembolism Incidence"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-2471","authenticated-orcid":false,"given":"Thakerng","family":"Pitakteerabundit","sequence":"first","affiliation":[{"name":"Department of Surgery Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-9815","authenticated-orcid":false,"given":"Utcharee","family":"Intusoma","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7855-3295","authenticated-orcid":false,"given":"Nan\u2010ak","family":"Wiboonkhwan","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-1459","authenticated-orcid":false,"given":"Tortrakoon","family":"Thongkan","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine, Prince of Songkla University  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2017.01.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010014\u20102763\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-1939-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477\u20102574.2012.00479.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.10.001"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12278"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000031948"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012385"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-022-06732-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hpb.2020.10.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH17-02-0134"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12796"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(91)91125-3"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1381\/096089205774859245"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2011.00319.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003493"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2010.12.002"},{"key":"e_1_2_11_19_1","unstructured":"R Core Team \u201cR: A Language and Environment for Statistical Computing. 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