{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:48:44Z","timestamp":1792532924574,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ANZ Journal of Surgery"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To validate magnetic resonance imaging (MRI)\u2010based prostate cancer risk calculators in an Australian population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data was retrospectively collected from patients biopsied at SALHN from May 2018 to March 2023. Men with MRI\u2010suspicious lesions underwent biopsy. Performance of nine risk calculators was evaluated by discrimination, decision curve analysis (DCA), calibration, and recalibration. Subgroup analysis of biopsy\u2010na\u00efve patients was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty\u2010two percent had clinically significant cancer (International Society of Urological Pathology [ISUP] Grade Group \u2265\u20092). Median age of 67\u2009years (IQR 62\u201367), PSA 7.3\u2009ng\/mL (IQR 5.3\u201311) and prostate volume 45\u2009mL (IQR 32\u2009mL\u201067\u2009mL) were observed. Abnormal DRE was recorded in 47%, and in 65% a Prostate Imaging\u2010Reporting and Data System (PIRADS) score of &gt;\u20094 was observed. The RPCRC and Mehralivand risk calculators demonstrated the best performance, with the Radtke risk calculator demonstrating adequate performance in the biopsy na\u00efve subgroup analysis. DCA demonstrated a net benefit of up to 12% of biopsies at a 15% risk threshold prior to recalibration. With recalibration, a net benefit of up to 6% at a 15% risk threshold was demonstrated. Analyses demonstrated a net benefit of up to 12.5% both pre and post recalibration in biopsy na\u00efve patients. Discriminative ability was at least &gt;\u20090.79, with most demonstrating discriminative ability &gt;\u20090.82.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Use of prostate biopsy decision\u2010making tools provides avenues for individualized health care based on patient\u2010specific risk factors. This study has successfully completed external validation of nine risk calculators, with one demonstrating adequate discriminatory capacity in all patients and three in biopsy\u2010na\u00efve patients. Systemic use may have a 12% net clinical benefit amongst biopsy\u2010na\u00efve patients, thereby reducing healthcare system burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ans.70211","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T08:09:52Z","timestamp":1751011792000},"page":"1906-1911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["External Validation of\n                    <scp>MRI<\/scp>\n                    \u2010Based Prostate Cancer Risk Calculators in an Australian Cohort"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-3660","authenticated-orcid":false,"given":"Nicole","family":"Williams","sequence":"first","affiliation":[{"name":"Urology Unit, Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"Remmers","sequence":"additional","affiliation":[{"name":"Department of Urology, Erasmus MC Cancer Institute University Medical Centre  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Jay","sequence":"additional","affiliation":[{"name":"Urology Unit, Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Santoro","sequence":"additional","affiliation":[{"name":"Urology Unit, Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"Urology Unit, Flinders Medical Centre  Bedford Park South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajur.2018.11.007"},{"key":"e_1_2_9_3_1","unstructured":"Department of Health and Aged Care \u201cMedicare Funding for New MRI Prostate Scans [Press Release] \u201d(2018)."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.07.031"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.4234"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13814"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.039"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.15835"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061589"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euros.2022.04.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2017.09.035"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.130"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6787"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16163"},{"key":"e_1_2_9_15_1","unstructured":"Australian Institute of Health and Welfare \u201cCancer Data in Australia \u201d(2020) https:\/\/www.aihw.gov.au\/reports\/cancer\/cancer\u2010data\u2010in\u2010australia\/contents\/summary."},{"key":"e_1_2_9_16_1","unstructured":"EAU Guidelines \u201cEdn. Presented at the EAU Annual Congress Milan \u201d(2023)."},{"key":"e_1_2_9_17_1","unstructured":"USANZ \u201cUSANZ Position Statement on MRI for Prostate Cancer 2016 \u201dUSANZ Position Statement on MRI for Prostate Cancer."}],"container-title":["ANZ Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70211","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ans.70211","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ans.70211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:42:26Z","timestamp":1772970146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ans.70211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/ans.70211"],"URL":"https:\/\/doi.org\/10.1111\/ans.70211","archive":["Portico"],"relation":{},"ISSN":["1445-1433","1445-2197"],"issn-type":[{"value":"1445-1433","type":"print"},{"value":"1445-2197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,27]]},"assertion":[{"value":"2025-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}